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Cancer cell killing by target antigen engagement with engineered complementary intracellular antibody single domains fused to pro-caspase3
Many tumour causing proteins, such as those expressed after chromosomal translocations or from point mutations, are intracellular and are not enzymes per se amenable to conventional drug targeting. We previously demonstrated an approach (Antibody-antigen Interaction Dependent Apoptosis (AIDA)) where...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6561968/ https://www.ncbi.nlm.nih.gov/pubmed/31189945 http://dx.doi.org/10.1038/s41598-019-44908-7 |