Scn1b deletion in adult mice results in seizures and SUDEP

Pathogenic loss‐of‐function variants in SCN1B are linked to Dravet syndrome (DS). Previous work suggested that neuronal pathfinding defects underlie epileptogenesis and SUDEP in the Scn1b null mouse model of DS. We tested this hypothesis by inducing Scn1b deletion in adult mice that had developed no...

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Detalles Bibliográficos
Autores principales: O'Malley, Heather A., Hull, Jacob M., Clawson, Brittany C., Chen, Chunling, Owens‐Fiestan, Gic, Jameson, Margaret B., Aton, Sara J., Parent, Jack M., Isom, Lori L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562025/
https://www.ncbi.nlm.nih.gov/pubmed/31211177
http://dx.doi.org/10.1002/acn3.785

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