CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis

The rarity of primary angiitis of the central nervous system (PACNS) demands diagnostic and prognostic biomarkers. We retrospectively measured Neurofilament light chain (NFL) concentrations in cerebrospinal fluid in a severely relapsing PACNS patient at multiple time points during the course of the...

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Detalles Bibliográficos
Autores principales: Pawlitzki, Marc, Butryn, Michaela, Kirchner, Florian, Färber, Jacqueline, Beuing, Oliver, Minnerup, Jens, Meuth, Sven G., Neumann, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562033/
https://www.ncbi.nlm.nih.gov/pubmed/31211179
http://dx.doi.org/10.1002/acn3.790
Descripción
Sumario:The rarity of primary angiitis of the central nervous system (PACNS) demands diagnostic and prognostic biomarkers. We retrospectively measured Neurofilament light chain (NFL) concentrations in cerebrospinal fluid in a severely relapsing PACNS patient at multiple time points during the course of the disease. A marked increase in NFL levels preceding the onset of neuro‐axonal damage and arterial‐vessel abnormalities was observed with magnetic resonance imaging as well as with MR‐ and conventional angiography. Thus, marked elevation of NFL in PACNS seems to occur ahead of definitive radiological abnormalities and might serve as a diagnostic biomarker.

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