CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis

The rarity of primary angiitis of the central nervous system (PACNS) demands diagnostic and prognostic biomarkers. We retrospectively measured Neurofilament light chain (NFL) concentrations in cerebrospinal fluid in a severely relapsing PACNS patient at multiple time points during the course of the...

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Autores principales: Pawlitzki, Marc, Butryn, Michaela, Kirchner, Florian, Färber, Jacqueline, Beuing, Oliver, Minnerup, Jens, Meuth, Sven G., Neumann, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Case Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562033/
https://www.ncbi.nlm.nih.gov/pubmed/31211179
http://dx.doi.org/10.1002/acn3.790
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author Pawlitzki, Marc
Butryn, Michaela
Kirchner, Florian
Färber, Jacqueline
Beuing, Oliver
Minnerup, Jens
Meuth, Sven G.
Neumann, Jens
author_facet Pawlitzki, Marc
Butryn, Michaela
Kirchner, Florian
Färber, Jacqueline
Beuing, Oliver
Minnerup, Jens
Meuth, Sven G.
Neumann, Jens
author_sort Pawlitzki, Marc
collection PubMed
description The rarity of primary angiitis of the central nervous system (PACNS) demands diagnostic and prognostic biomarkers. We retrospectively measured Neurofilament light chain (NFL) concentrations in cerebrospinal fluid in a severely relapsing PACNS patient at multiple time points during the course of the disease. A marked increase in NFL levels preceding the onset of neuro‐axonal damage and arterial‐vessel abnormalities was observed with magnetic resonance imaging as well as with MR‐ and conventional angiography. Thus, marked elevation of NFL in PACNS seems to occur ahead of definitive radiological abnormalities and might serve as a diagnostic biomarker.
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spelling pubmed-65620332019-06-17 CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis Pawlitzki, Marc Butryn, Michaela Kirchner, Florian Färber, Jacqueline Beuing, Oliver Minnerup, Jens Meuth, Sven G. Neumann, Jens Ann Clin Transl Neurol Case Study The rarity of primary angiitis of the central nervous system (PACNS) demands diagnostic and prognostic biomarkers. We retrospectively measured Neurofilament light chain (NFL) concentrations in cerebrospinal fluid in a severely relapsing PACNS patient at multiple time points during the course of the disease. A marked increase in NFL levels preceding the onset of neuro‐axonal damage and arterial‐vessel abnormalities was observed with magnetic resonance imaging as well as with MR‐ and conventional angiography. Thus, marked elevation of NFL in PACNS seems to occur ahead of definitive radiological abnormalities and might serve as a diagnostic biomarker. John Wiley and Sons Inc. 2019-06-03 /pmc/articles/PMC6562033/ /pubmed/31211179 http://dx.doi.org/10.1002/acn3.790 Text en © 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Study
Pawlitzki, Marc
Butryn, Michaela
Kirchner, Florian
Färber, Jacqueline
Beuing, Oliver
Minnerup, Jens
Meuth, Sven G.
Neumann, Jens
CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis
title CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis
title_full CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis
title_fullStr CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis
title_full_unstemmed CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis
title_short CSF Neurofilament light chain level predicts axonal damage in cerebral vasculitis
title_sort csf neurofilament light chain level predicts axonal damage in cerebral vasculitis
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562033/
https://www.ncbi.nlm.nih.gov/pubmed/31211179
http://dx.doi.org/10.1002/acn3.790
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