Cargando…
The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study
BACKGROUND: Cardiovascular disease is a major cause of death in endometrial cancer survivors. The aim of this study was to determine whether women newly diagnosed with endometrial cancer have a higher prevalence of cardiovascular risk factors than the general population. METHODS: The prevalence of a...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academic Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562057/ https://www.ncbi.nlm.nih.gov/pubmed/29174567 http://dx.doi.org/10.1016/j.ygyno.2017.11.019 |
_version_ | 1783426225280122880 |
---|---|
author | Kitson, Sarah J. Lindsay, Jennifer Sivalingam, Vanitha N. Lunt, Mark Ryan, Neil A.J. Edmondson, Richard J. Rutter, Martin K. Crosbie, Emma J. |
author_facet | Kitson, Sarah J. Lindsay, Jennifer Sivalingam, Vanitha N. Lunt, Mark Ryan, Neil A.J. Edmondson, Richard J. Rutter, Martin K. Crosbie, Emma J. |
author_sort | Kitson, Sarah J. |
collection | PubMed |
description | BACKGROUND: Cardiovascular disease is a major cause of death in endometrial cancer survivors. The aim of this study was to determine whether women newly diagnosed with endometrial cancer have a higher prevalence of cardiovascular risk factors than the general population. METHODS: The prevalence of adequately treated and unrecognized/inadequately treated cardiovascular risk factors and the corresponding 10-year cardiovascular risk by QRISK2 score was measured in 150 consecutive women undergoing primary treatment for endometrioid endometrial cancer in the North West of England, and 746 age and ethnicity-matched control women from the Health Survey for England 2014. RESULTS: Women with endometrial cancer had higher proportions of obesity (BMI ≥ 30 60.7% vs. 32.4%, p < 0.0001) and a preponderance of unrecognized and inadequately treated cardiovascular risk factors. Compared with controls, endometrial cancer cases had a higher prevalence of incident hyperglycemia (57.2% vs. 11.5%, p < 0.0001), total: HDL cholesterol ratio > 4.5 (26.7% vs. 13.7%, p < 0.0001), and were more likely to have three or more cardiovascular risk factors (22% vs. 6%, p < 0.0001). This equates to a higher 10-year cardiovascular risk (median QRISK2 score 12.6% vs. 8.8%, p < 0.0001). Optimization of risk factors would have a greater impact on absolute cardiovascular disease risk for cases than controls (QRISK2 score reduction 1.8% vs. 0.7%). CONCLUSIONS: Women undergoing primary treatment for endometrial cancer have a higher prevalence of cardiovascular risk factors than women without the disease. Early identification and treatment of these risk factors could improve outcomes for endometrial cancer survivors. |
format | Online Article Text |
id | pubmed-6562057 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Academic Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-65620572019-06-17 The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study Kitson, Sarah J. Lindsay, Jennifer Sivalingam, Vanitha N. Lunt, Mark Ryan, Neil A.J. Edmondson, Richard J. Rutter, Martin K. Crosbie, Emma J. Gynecol Oncol Article BACKGROUND: Cardiovascular disease is a major cause of death in endometrial cancer survivors. The aim of this study was to determine whether women newly diagnosed with endometrial cancer have a higher prevalence of cardiovascular risk factors than the general population. METHODS: The prevalence of adequately treated and unrecognized/inadequately treated cardiovascular risk factors and the corresponding 10-year cardiovascular risk by QRISK2 score was measured in 150 consecutive women undergoing primary treatment for endometrioid endometrial cancer in the North West of England, and 746 age and ethnicity-matched control women from the Health Survey for England 2014. RESULTS: Women with endometrial cancer had higher proportions of obesity (BMI ≥ 30 60.7% vs. 32.4%, p < 0.0001) and a preponderance of unrecognized and inadequately treated cardiovascular risk factors. Compared with controls, endometrial cancer cases had a higher prevalence of incident hyperglycemia (57.2% vs. 11.5%, p < 0.0001), total: HDL cholesterol ratio > 4.5 (26.7% vs. 13.7%, p < 0.0001), and were more likely to have three or more cardiovascular risk factors (22% vs. 6%, p < 0.0001). This equates to a higher 10-year cardiovascular risk (median QRISK2 score 12.6% vs. 8.8%, p < 0.0001). Optimization of risk factors would have a greater impact on absolute cardiovascular disease risk for cases than controls (QRISK2 score reduction 1.8% vs. 0.7%). CONCLUSIONS: Women undergoing primary treatment for endometrial cancer have a higher prevalence of cardiovascular risk factors than women without the disease. Early identification and treatment of these risk factors could improve outcomes for endometrial cancer survivors. Academic Press 2018-01 /pmc/articles/PMC6562057/ /pubmed/29174567 http://dx.doi.org/10.1016/j.ygyno.2017.11.019 Text en © 2018 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kitson, Sarah J. Lindsay, Jennifer Sivalingam, Vanitha N. Lunt, Mark Ryan, Neil A.J. Edmondson, Richard J. Rutter, Martin K. Crosbie, Emma J. The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study |
title | The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study |
title_full | The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study |
title_fullStr | The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study |
title_full_unstemmed | The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study |
title_short | The unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: A prospective case control study |
title_sort | unrecognized burden of cardiovascular risk factors in women newly diagnosed with endometrial cancer: a prospective case control study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562057/ https://www.ncbi.nlm.nih.gov/pubmed/29174567 http://dx.doi.org/10.1016/j.ygyno.2017.11.019 |
work_keys_str_mv | AT kitsonsarahj theunrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT lindsayjennifer theunrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT sivalingamvanithan theunrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT luntmark theunrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT ryanneilaj theunrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT edmondsonrichardj theunrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT ruttermartink theunrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT crosbieemmaj theunrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT kitsonsarahj unrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT lindsayjennifer unrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT sivalingamvanithan unrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT luntmark unrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT ryanneilaj unrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT edmondsonrichardj unrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT ruttermartink unrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy AT crosbieemmaj unrecognizedburdenofcardiovascularriskfactorsinwomennewlydiagnosedwithendometrialcanceraprospectivecasecontrolstudy |