Disrupted folate metabolism with anesthesia leads to myelination deficits mediated by epigenetic regulation of ERMN

BACKGROUND: Exposure to anesthetics during early life may impair cognitive functions. However, the underlying mechanisms remain largely unknown. We set out to determine effects of sevoflurane anesthesia on folate metabolism and myelination in young non-human primates, mice and children. METHODS: You...

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Detalles Bibliográficos
Autores principales: Zhang, Lei, Xue, Zhenyu, Liu, Qidong, Liu, Yunbo, Xi, Siwei, Cheng, Yanyong, Li, Jingjie, Yan, Jia, Shen, Yuan, Xiao, Chong, Xie, Zhongcong, Qiu, Zilong, Jiang, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562069/
https://www.ncbi.nlm.nih.gov/pubmed/31060905
http://dx.doi.org/10.1016/j.ebiom.2019.04.048

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