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Effects of exogenous oxytocin and atosiban antagonist on GABA in different region of brain

Gamma amino butyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebral central nervous system. It functions by altering the membrane conductance of Cl(−) ions, maintaining the membrane potential close to the resting potential. The hormone oxytocin (OT) has a central action where...

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Detalles Bibliográficos
Autores principales: Thakur, Pratibha, Shrivastava, Renu, Shrivastava, Vinoy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562178/
https://www.ncbi.nlm.nih.gov/pubmed/31211283
http://dx.doi.org/10.1016/j.ibror.2019.04.001
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author Thakur, Pratibha
Shrivastava, Renu
Shrivastava, Vinoy K.
author_facet Thakur, Pratibha
Shrivastava, Renu
Shrivastava, Vinoy K.
author_sort Thakur, Pratibha
collection PubMed
description Gamma amino butyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebral central nervous system. It functions by altering the membrane conductance of Cl(−) ions, maintaining the membrane potential close to the resting potential. The hormone oxytocin (OT) has a central action where it acts as a neuromodulatory peptide and exerts its action depending upon the distribution of OT receptors (OTR) in the target site. OTRs are G-protein-coupled receptors (GPCRs) comprising different subunits (Gq, Gi, and Gs). The G- protein isoforms have the ability to activate different pathways, but specific agonists and antagonists may show different affinities to OTRs, depending on the specific G-protein isoform to which they are coupled. It is well documented that OTR distribution varies with age and species and in regions of the brain. In this study, we attempted to observe the impact of OT and atosiban (OTA), an OT antagonist, on GABA levels in different regions of the brain. Study animals were exposed intraperitoneally (i.p.) to normal saline (0.89%), OT 0.0116 mg/kg, and OTA 1 mg/kg in different combinations, for 30days. It was observed that OT and OTA administration modulated GABA levels in different regions of brain, while normal saline had no effect. It may be due to OTR receptor expression in different regions of the brain. This is significant because region-specific expression of different receptors could be important in the development of new drugs targeting specific neuropsychiatric disorders.
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spelling pubmed-65621782019-06-17 Effects of exogenous oxytocin and atosiban antagonist on GABA in different region of brain Thakur, Pratibha Shrivastava, Renu Shrivastava, Vinoy K. IBRO Rep Article Gamma amino butyric acid (GABA) is the primary inhibitory neurotransmitter in the vertebral central nervous system. It functions by altering the membrane conductance of Cl(−) ions, maintaining the membrane potential close to the resting potential. The hormone oxytocin (OT) has a central action where it acts as a neuromodulatory peptide and exerts its action depending upon the distribution of OT receptors (OTR) in the target site. OTRs are G-protein-coupled receptors (GPCRs) comprising different subunits (Gq, Gi, and Gs). The G- protein isoforms have the ability to activate different pathways, but specific agonists and antagonists may show different affinities to OTRs, depending on the specific G-protein isoform to which they are coupled. It is well documented that OTR distribution varies with age and species and in regions of the brain. In this study, we attempted to observe the impact of OT and atosiban (OTA), an OT antagonist, on GABA levels in different regions of the brain. Study animals were exposed intraperitoneally (i.p.) to normal saline (0.89%), OT 0.0116 mg/kg, and OTA 1 mg/kg in different combinations, for 30days. It was observed that OT and OTA administration modulated GABA levels in different regions of brain, while normal saline had no effect. It may be due to OTR receptor expression in different regions of the brain. This is significant because region-specific expression of different receptors could be important in the development of new drugs targeting specific neuropsychiatric disorders. Elsevier 2019-04-17 /pmc/articles/PMC6562178/ /pubmed/31211283 http://dx.doi.org/10.1016/j.ibror.2019.04.001 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Thakur, Pratibha
Shrivastava, Renu
Shrivastava, Vinoy K.
Effects of exogenous oxytocin and atosiban antagonist on GABA in different region of brain
title Effects of exogenous oxytocin and atosiban antagonist on GABA in different region of brain
title_full Effects of exogenous oxytocin and atosiban antagonist on GABA in different region of brain
title_fullStr Effects of exogenous oxytocin and atosiban antagonist on GABA in different region of brain
title_full_unstemmed Effects of exogenous oxytocin and atosiban antagonist on GABA in different region of brain
title_short Effects of exogenous oxytocin and atosiban antagonist on GABA in different region of brain
title_sort effects of exogenous oxytocin and atosiban antagonist on gaba in different region of brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562178/
https://www.ncbi.nlm.nih.gov/pubmed/31211283
http://dx.doi.org/10.1016/j.ibror.2019.04.001
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