Complete response to perioperative treatment using nivolumab for metastatic renal cell carcinoma: A case report

We report a case of 59-year-old woman who has multiple lung metastases with renal cell carcinoma (RCC). She received neoadjuvant therapy using nivolumab following sunitinib. Thereafter, we performed cytoreductive nephrectomy and subsequently administered nivolumab. We also found a high expression of...

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Detalles Bibliográficos
Autores principales: Ikarashi, Daiki, Nakamura, Yasuyuki, Shimodate, Hitoshi, Usui, Yoshitaka, Ujiie, Takashi, Obara, Wataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Trauma and Reconstruction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562266/
https://www.ncbi.nlm.nih.gov/pubmed/31211050
http://dx.doi.org/10.1016/j.eucr.2019.100839
Descripción
Sumario:We report a case of 59-year-old woman who has multiple lung metastases with renal cell carcinoma (RCC). She received neoadjuvant therapy using nivolumab following sunitinib. Thereafter, we performed cytoreductive nephrectomy and subsequently administered nivolumab. We also found a high expression of PD-L1 in tumor cell and infiltration of lymphocytes with CD8 expression by immunohistochemistry. A complete response was achieved 4 months after surgery. A perioperative treatment using nivolumab might be useful treatment for metastatic RCC.

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