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The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling
Hippo signaling controls cellular processes that ultimately impact organogenesis and homeostasis. Consequently, disease states including cancer can emerge when signaling is deregulated. The major pathway transducers Yap and Taz require cofactors to impart transcriptional control over target genes. R...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562424/ https://www.ncbi.nlm.nih.gov/pubmed/31137701 http://dx.doi.org/10.3390/cells8050502 |
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author | Hillmer, Ryan E. Link, Brian A. |
author_facet | Hillmer, Ryan E. Link, Brian A. |
author_sort | Hillmer, Ryan E. |
collection | PubMed |
description | Hippo signaling controls cellular processes that ultimately impact organogenesis and homeostasis. Consequently, disease states including cancer can emerge when signaling is deregulated. The major pathway transducers Yap and Taz require cofactors to impart transcriptional control over target genes. Research into Yap/Taz-mediated epigenetic modifications has revealed their association with chromatin-remodeling complex proteins as a means of altering chromatin structure, therefore affecting accessibility and activity of target genes. Specifically, Yap/Taz have been found to associate with factors of the GAGA, Ncoa6, Mediator, Switch/sucrose nonfermentable (SWI/SNF), and Nucleosome Remodeling and Deacetylase (NuRD) chromatin-remodeling complexes to alter the accessibility of target genes. This review highlights the different mechanisms by which Yap/Taz collaborate with other factors to modify DNA packing at specific loci to either activate or repress target gene transcription. |
format | Online Article Text |
id | pubmed-6562424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65624242019-06-17 The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling Hillmer, Ryan E. Link, Brian A. Cells Review Hippo signaling controls cellular processes that ultimately impact organogenesis and homeostasis. Consequently, disease states including cancer can emerge when signaling is deregulated. The major pathway transducers Yap and Taz require cofactors to impart transcriptional control over target genes. Research into Yap/Taz-mediated epigenetic modifications has revealed their association with chromatin-remodeling complex proteins as a means of altering chromatin structure, therefore affecting accessibility and activity of target genes. Specifically, Yap/Taz have been found to associate with factors of the GAGA, Ncoa6, Mediator, Switch/sucrose nonfermentable (SWI/SNF), and Nucleosome Remodeling and Deacetylase (NuRD) chromatin-remodeling complexes to alter the accessibility of target genes. This review highlights the different mechanisms by which Yap/Taz collaborate with other factors to modify DNA packing at specific loci to either activate or repress target gene transcription. MDPI 2019-05-24 /pmc/articles/PMC6562424/ /pubmed/31137701 http://dx.doi.org/10.3390/cells8050502 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hillmer, Ryan E. Link, Brian A. The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling |
title | The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling |
title_full | The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling |
title_fullStr | The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling |
title_full_unstemmed | The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling |
title_short | The Roles of Hippo Signaling Transducers Yap and Taz in Chromatin Remodeling |
title_sort | roles of hippo signaling transducers yap and taz in chromatin remodeling |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562424/ https://www.ncbi.nlm.nih.gov/pubmed/31137701 http://dx.doi.org/10.3390/cells8050502 |
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