Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049

Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivati...

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Autores principales: Xu, Xiuli, Han, Jiahui, Wang, Yanan, Lin, Rui, Yang, Haijin, Li, Jiangpeng, Wei, Shangzhu, Polyak, Steven W., Song, Fuhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562449/
https://www.ncbi.nlm.nih.gov/pubmed/31091673
http://dx.doi.org/10.3390/md17050289
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author Xu, Xiuli
Han, Jiahui
Wang, Yanan
Lin, Rui
Yang, Haijin
Li, Jiangpeng
Wei, Shangzhu
Polyak, Steven W.
Song, Fuhang
author_facet Xu, Xiuli
Han, Jiahui
Wang, Yanan
Lin, Rui
Yang, Haijin
Li, Jiangpeng
Wei, Shangzhu
Polyak, Steven W.
Song, Fuhang
author_sort Xu, Xiuli
collection PubMed
description Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivatives, 16-O-propionyl-16-O-deacetylhelvolic acid (5), 6-O-propionyl-6-O-deacetylhelvolic acid (6), helvolic acid (7), and 1,2-dihydrohelvolic acid (8) were also identified. One-dimensional (1D), two-dimensional (2D) NMR, HRMS, and circular dichroism spectral analysis characterized the structures of the isolated compounds.
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spelling pubmed-65624492019-06-17 Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049 Xu, Xiuli Han, Jiahui Wang, Yanan Lin, Rui Yang, Haijin Li, Jiangpeng Wei, Shangzhu Polyak, Steven W. Song, Fuhang Mar Drugs Article Two new spiro-heterocyclic γ-lactam derivatives, cephalimysins M (1) and N (2), were isolated from the fermentation cultures of the marine-derived fungus Aspergillus fumigatus CUGBMF17018. Two known analogues, pseurotin A (3) and FD-838 (4), as well as four previously reported helvolic acid derivatives, 16-O-propionyl-16-O-deacetylhelvolic acid (5), 6-O-propionyl-6-O-deacetylhelvolic acid (6), helvolic acid (7), and 1,2-dihydrohelvolic acid (8) were also identified. One-dimensional (1D), two-dimensional (2D) NMR, HRMS, and circular dichroism spectral analysis characterized the structures of the isolated compounds. MDPI 2019-05-14 /pmc/articles/PMC6562449/ /pubmed/31091673 http://dx.doi.org/10.3390/md17050289 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Xiuli
Han, Jiahui
Wang, Yanan
Lin, Rui
Yang, Haijin
Li, Jiangpeng
Wei, Shangzhu
Polyak, Steven W.
Song, Fuhang
Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049
title Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049
title_full Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049
title_fullStr Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049
title_full_unstemmed Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049
title_short Two New Spiro-Heterocyclic γ-Lactams from A Marine-Derived Aspergillus fumigatus Strain CUGBMF170049
title_sort two new spiro-heterocyclic γ-lactams from a marine-derived aspergillus fumigatus strain cugbmf170049
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562449/
https://www.ncbi.nlm.nih.gov/pubmed/31091673
http://dx.doi.org/10.3390/md17050289
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