Oligodeoxynucleotides ODN 2006 and M362 Exert Potent Adjuvant Effect through TLR-9/-6 Synergy to Exaggerate Mammaglobin-A Peptide Specific Cytotoxic CD8+T Lymphocyte Responses against Breast Cancer Cells

Mammaglobin-A (MamA) is overexpressed in 40–80% of all human breast cancers. Recent phase I clinical trials of the MamA DNA vaccine showed encouraging safety outcomes. However, this vaccine elicited only a modest increase in MamA specific CD8+T lymphocyte (CTL) activation. As vaccine adjuvants play...

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Detalles Bibliográficos
Autores principales: Babaer, Duaa, Amara, Suneetha, McAdory, Brenda S., Johnson, Owen, Myles, Elbert L., Zent, Roy, Rathmell, Jeffrey C., Tiriveedhi, Venkataswarup
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562487/
https://www.ncbi.nlm.nih.gov/pubmed/31091800
http://dx.doi.org/10.3390/cancers11050672

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