Cargando…
Cognitive Decline Secondary to Therapeutic Brain Radiation—Similarities and Differences to Traumatic Brain Injury
Traumatic brain injury (TBI) resulting from forceful impacts on the torso and head has been of major interest because of the prevalence of such injuries in military personnel, contact sports and the elderly. Cognitive and behavioral changes associated with TBI are also seen following whole brain rad...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562497/ https://www.ncbi.nlm.nih.gov/pubmed/31035608 http://dx.doi.org/10.3390/brainsci9050097 |
_version_ | 1783426314359799808 |
---|---|
author | Huang, Andrew Jonathan Kornguth, David Kornguth, Steven |
author_facet | Huang, Andrew Jonathan Kornguth, David Kornguth, Steven |
author_sort | Huang, Andrew Jonathan |
collection | PubMed |
description | Traumatic brain injury (TBI) resulting from forceful impacts on the torso and head has been of major interest because of the prevalence of such injuries in military personnel, contact sports and the elderly. Cognitive and behavioral changes associated with TBI are also seen following whole brain radiation treatment for cancer and chemotherapy for disseminated tumors. The biological mechanisms involved in the initiation of TBI from impact, radiation, and chemotherapy to loss of cognitive function have several shared characteristics including increases in blood brain barrier permeability, blood vessel density, increases in inflammatory and autoimmune responses, alterations in NMDA and glutamate receptor levels and release of proteins normally sequestered in the brain into the blood and spinal fluid. The development of therapeutic agents that mitigate the loss of cognition and development of behavioral disorders in patients experiencing radiation-induced injury may provide benefit to those with TBI when similar processes are involved on a cellular or molecular level. Increased collaborative efforts between the radiation oncology and the neurology and psychiatry communities may be of major benefit for the management of brain injury from varied environmental insults. |
format | Online Article Text |
id | pubmed-6562497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65624972019-06-17 Cognitive Decline Secondary to Therapeutic Brain Radiation—Similarities and Differences to Traumatic Brain Injury Huang, Andrew Jonathan Kornguth, David Kornguth, Steven Brain Sci Perspective Traumatic brain injury (TBI) resulting from forceful impacts on the torso and head has been of major interest because of the prevalence of such injuries in military personnel, contact sports and the elderly. Cognitive and behavioral changes associated with TBI are also seen following whole brain radiation treatment for cancer and chemotherapy for disseminated tumors. The biological mechanisms involved in the initiation of TBI from impact, radiation, and chemotherapy to loss of cognitive function have several shared characteristics including increases in blood brain barrier permeability, blood vessel density, increases in inflammatory and autoimmune responses, alterations in NMDA and glutamate receptor levels and release of proteins normally sequestered in the brain into the blood and spinal fluid. The development of therapeutic agents that mitigate the loss of cognition and development of behavioral disorders in patients experiencing radiation-induced injury may provide benefit to those with TBI when similar processes are involved on a cellular or molecular level. Increased collaborative efforts between the radiation oncology and the neurology and psychiatry communities may be of major benefit for the management of brain injury from varied environmental insults. MDPI 2019-04-27 /pmc/articles/PMC6562497/ /pubmed/31035608 http://dx.doi.org/10.3390/brainsci9050097 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Perspective Huang, Andrew Jonathan Kornguth, David Kornguth, Steven Cognitive Decline Secondary to Therapeutic Brain Radiation—Similarities and Differences to Traumatic Brain Injury |
title | Cognitive Decline Secondary to Therapeutic Brain Radiation—Similarities and Differences to Traumatic Brain Injury |
title_full | Cognitive Decline Secondary to Therapeutic Brain Radiation—Similarities and Differences to Traumatic Brain Injury |
title_fullStr | Cognitive Decline Secondary to Therapeutic Brain Radiation—Similarities and Differences to Traumatic Brain Injury |
title_full_unstemmed | Cognitive Decline Secondary to Therapeutic Brain Radiation—Similarities and Differences to Traumatic Brain Injury |
title_short | Cognitive Decline Secondary to Therapeutic Brain Radiation—Similarities and Differences to Traumatic Brain Injury |
title_sort | cognitive decline secondary to therapeutic brain radiation—similarities and differences to traumatic brain injury |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562497/ https://www.ncbi.nlm.nih.gov/pubmed/31035608 http://dx.doi.org/10.3390/brainsci9050097 |
work_keys_str_mv | AT huangandrewjonathan cognitivedeclinesecondarytotherapeuticbrainradiationsimilaritiesanddifferencestotraumaticbraininjury AT kornguthdavid cognitivedeclinesecondarytotherapeuticbrainradiationsimilaritiesanddifferencestotraumaticbraininjury AT kornguthsteven cognitivedeclinesecondarytotherapeuticbrainradiationsimilaritiesanddifferencestotraumaticbraininjury |