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Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry

A needle-to-cylinder electrode, adopted as an ion source for high-field asymmetric ion mobility spectrometry (FAIMS), is designed and fabricated by lithographie, galvanoformung and abformung (LIGA) technology. The needle, with a tip diameter of 20 μm and thickness of 20 μm, and a cylinder, with a di...

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Autores principales: Li, Hua, Yun, Hongmei, Du, Xiaoxia, Guo, Chaoqun, Zeng, Ruosheng, Jiang, Yongrong, Chen, Zhencheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562519/
https://www.ncbi.nlm.nih.gov/pubmed/31035626
http://dx.doi.org/10.3390/mi10050286
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author Li, Hua
Yun, Hongmei
Du, Xiaoxia
Guo, Chaoqun
Zeng, Ruosheng
Jiang, Yongrong
Chen, Zhencheng
author_facet Li, Hua
Yun, Hongmei
Du, Xiaoxia
Guo, Chaoqun
Zeng, Ruosheng
Jiang, Yongrong
Chen, Zhencheng
author_sort Li, Hua
collection PubMed
description A needle-to-cylinder electrode, adopted as an ion source for high-field asymmetric ion mobility spectrometry (FAIMS), is designed and fabricated by lithographie, galvanoformung and abformung (LIGA) technology. The needle, with a tip diameter of 20 μm and thickness of 20 μm, and a cylinder, with a diameter of 400 μm, were connected to the negative high voltage and ground, respectively. A negative corona and glow discharge were realized. For acetone with a density of 99.7 ppm, ethanol with a density of 300 ppm, and acetic ether with a density of 99.3 ppm, the sample gas was ionized by the needle-to-cylinder chip and the ions were detected by an LTQ XL™ (Thermo Scientific Corp.) mass spectrometer. The mass spectra show that the ions are mainly the protonated monomer, the proton bound dimer, and an ion-H(2)O molecule cluster. In tandem with a FAIMS system, the FAIMS spectra show that the resolving power increases with an increase in the RF voltage. The obtained experimental results showed that the micro needle-to-cylinder chip may serve as a miniature, low cost and non-radioactive ion source for FAIMS.
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spelling pubmed-65625192019-06-17 Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry Li, Hua Yun, Hongmei Du, Xiaoxia Guo, Chaoqun Zeng, Ruosheng Jiang, Yongrong Chen, Zhencheng Micromachines (Basel) Article A needle-to-cylinder electrode, adopted as an ion source for high-field asymmetric ion mobility spectrometry (FAIMS), is designed and fabricated by lithographie, galvanoformung and abformung (LIGA) technology. The needle, with a tip diameter of 20 μm and thickness of 20 μm, and a cylinder, with a diameter of 400 μm, were connected to the negative high voltage and ground, respectively. A negative corona and glow discharge were realized. For acetone with a density of 99.7 ppm, ethanol with a density of 300 ppm, and acetic ether with a density of 99.3 ppm, the sample gas was ionized by the needle-to-cylinder chip and the ions were detected by an LTQ XL™ (Thermo Scientific Corp.) mass spectrometer. The mass spectra show that the ions are mainly the protonated monomer, the proton bound dimer, and an ion-H(2)O molecule cluster. In tandem with a FAIMS system, the FAIMS spectra show that the resolving power increases with an increase in the RF voltage. The obtained experimental results showed that the micro needle-to-cylinder chip may serve as a miniature, low cost and non-radioactive ion source for FAIMS. MDPI 2019-04-27 /pmc/articles/PMC6562519/ /pubmed/31035626 http://dx.doi.org/10.3390/mi10050286 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Hua
Yun, Hongmei
Du, Xiaoxia
Guo, Chaoqun
Zeng, Ruosheng
Jiang, Yongrong
Chen, Zhencheng
Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry
title Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry
title_full Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry
title_fullStr Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry
title_full_unstemmed Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry
title_short Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry
title_sort design, fabrication and mass-spectrometric studies of a micro ion source for high-field asymmetric waveform ion mobility spectrometry
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562519/
https://www.ncbi.nlm.nih.gov/pubmed/31035626
http://dx.doi.org/10.3390/mi10050286
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