Cargando…
Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry
A needle-to-cylinder electrode, adopted as an ion source for high-field asymmetric ion mobility spectrometry (FAIMS), is designed and fabricated by lithographie, galvanoformung and abformung (LIGA) technology. The needle, with a tip diameter of 20 μm and thickness of 20 μm, and a cylinder, with a di...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562519/ https://www.ncbi.nlm.nih.gov/pubmed/31035626 http://dx.doi.org/10.3390/mi10050286 |
_version_ | 1783426319575416832 |
---|---|
author | Li, Hua Yun, Hongmei Du, Xiaoxia Guo, Chaoqun Zeng, Ruosheng Jiang, Yongrong Chen, Zhencheng |
author_facet | Li, Hua Yun, Hongmei Du, Xiaoxia Guo, Chaoqun Zeng, Ruosheng Jiang, Yongrong Chen, Zhencheng |
author_sort | Li, Hua |
collection | PubMed |
description | A needle-to-cylinder electrode, adopted as an ion source for high-field asymmetric ion mobility spectrometry (FAIMS), is designed and fabricated by lithographie, galvanoformung and abformung (LIGA) technology. The needle, with a tip diameter of 20 μm and thickness of 20 μm, and a cylinder, with a diameter of 400 μm, were connected to the negative high voltage and ground, respectively. A negative corona and glow discharge were realized. For acetone with a density of 99.7 ppm, ethanol with a density of 300 ppm, and acetic ether with a density of 99.3 ppm, the sample gas was ionized by the needle-to-cylinder chip and the ions were detected by an LTQ XL™ (Thermo Scientific Corp.) mass spectrometer. The mass spectra show that the ions are mainly the protonated monomer, the proton bound dimer, and an ion-H(2)O molecule cluster. In tandem with a FAIMS system, the FAIMS spectra show that the resolving power increases with an increase in the RF voltage. The obtained experimental results showed that the micro needle-to-cylinder chip may serve as a miniature, low cost and non-radioactive ion source for FAIMS. |
format | Online Article Text |
id | pubmed-6562519 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65625192019-06-17 Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry Li, Hua Yun, Hongmei Du, Xiaoxia Guo, Chaoqun Zeng, Ruosheng Jiang, Yongrong Chen, Zhencheng Micromachines (Basel) Article A needle-to-cylinder electrode, adopted as an ion source for high-field asymmetric ion mobility spectrometry (FAIMS), is designed and fabricated by lithographie, galvanoformung and abformung (LIGA) technology. The needle, with a tip diameter of 20 μm and thickness of 20 μm, and a cylinder, with a diameter of 400 μm, were connected to the negative high voltage and ground, respectively. A negative corona and glow discharge were realized. For acetone with a density of 99.7 ppm, ethanol with a density of 300 ppm, and acetic ether with a density of 99.3 ppm, the sample gas was ionized by the needle-to-cylinder chip and the ions were detected by an LTQ XL™ (Thermo Scientific Corp.) mass spectrometer. The mass spectra show that the ions are mainly the protonated monomer, the proton bound dimer, and an ion-H(2)O molecule cluster. In tandem with a FAIMS system, the FAIMS spectra show that the resolving power increases with an increase in the RF voltage. The obtained experimental results showed that the micro needle-to-cylinder chip may serve as a miniature, low cost and non-radioactive ion source for FAIMS. MDPI 2019-04-27 /pmc/articles/PMC6562519/ /pubmed/31035626 http://dx.doi.org/10.3390/mi10050286 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Li, Hua Yun, Hongmei Du, Xiaoxia Guo, Chaoqun Zeng, Ruosheng Jiang, Yongrong Chen, Zhencheng Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry |
title | Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry |
title_full | Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry |
title_fullStr | Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry |
title_full_unstemmed | Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry |
title_short | Design, Fabrication and Mass-spectrometric Studies of a Micro Ion Source for High-Field Asymmetric Waveform Ion Mobility Spectrometry |
title_sort | design, fabrication and mass-spectrometric studies of a micro ion source for high-field asymmetric waveform ion mobility spectrometry |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562519/ https://www.ncbi.nlm.nih.gov/pubmed/31035626 http://dx.doi.org/10.3390/mi10050286 |
work_keys_str_mv | AT lihua designfabricationandmassspectrometricstudiesofamicroionsourceforhighfieldasymmetricwaveformionmobilityspectrometry AT yunhongmei designfabricationandmassspectrometricstudiesofamicroionsourceforhighfieldasymmetricwaveformionmobilityspectrometry AT duxiaoxia designfabricationandmassspectrometricstudiesofamicroionsourceforhighfieldasymmetricwaveformionmobilityspectrometry AT guochaoqun designfabricationandmassspectrometricstudiesofamicroionsourceforhighfieldasymmetricwaveformionmobilityspectrometry AT zengruosheng designfabricationandmassspectrometricstudiesofamicroionsourceforhighfieldasymmetricwaveformionmobilityspectrometry AT jiangyongrong designfabricationandmassspectrometricstudiesofamicroionsourceforhighfieldasymmetricwaveformionmobilityspectrometry AT chenzhencheng designfabricationandmassspectrometricstudiesofamicroionsourceforhighfieldasymmetricwaveformionmobilityspectrometry |