Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension

Pulmonary arterial hypertension (PAH) is one of the diseases with a well-established gender dimorphism. The prevalence of PAH is increased in females with a ratio of 4:1, while poor survival prognosis is associated with the male gender. Nevertheless, the specific contribution of gender in disease de...

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Autores principales: Rafikov, Ruslan, James, Joel, McClain, Nolan, Tofovic, Stevan P., Rafikova, Olga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562572/
https://www.ncbi.nlm.nih.gov/pubmed/31100969
http://dx.doi.org/10.3390/antiox8050135
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author Rafikov, Ruslan
James, Joel
McClain, Nolan
Tofovic, Stevan P.
Rafikova, Olga
author_facet Rafikov, Ruslan
James, Joel
McClain, Nolan
Tofovic, Stevan P.
Rafikova, Olga
author_sort Rafikov, Ruslan
collection PubMed
description Pulmonary arterial hypertension (PAH) is one of the diseases with a well-established gender dimorphism. The prevalence of PAH is increased in females with a ratio of 4:1, while poor survival prognosis is associated with the male gender. Nevertheless, the specific contribution of gender in disease development and progression is unclear due to the complex nature of the PAH. Oxidative and nitrosative stresses are important contributors in PAH pathogenesis; however, the role of gender in redox homeostasis has been understudied. This review is aimed to overview the possible sex-specific mechanisms responsible for the regulation of the balance between oxidants and antioxidants in relation to PAH pathobiology.
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spelling pubmed-65625722019-06-17 Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension Rafikov, Ruslan James, Joel McClain, Nolan Tofovic, Stevan P. Rafikova, Olga Antioxidants (Basel) Review Pulmonary arterial hypertension (PAH) is one of the diseases with a well-established gender dimorphism. The prevalence of PAH is increased in females with a ratio of 4:1, while poor survival prognosis is associated with the male gender. Nevertheless, the specific contribution of gender in disease development and progression is unclear due to the complex nature of the PAH. Oxidative and nitrosative stresses are important contributors in PAH pathogenesis; however, the role of gender in redox homeostasis has been understudied. This review is aimed to overview the possible sex-specific mechanisms responsible for the regulation of the balance between oxidants and antioxidants in relation to PAH pathobiology. MDPI 2019-05-16 /pmc/articles/PMC6562572/ /pubmed/31100969 http://dx.doi.org/10.3390/antiox8050135 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rafikov, Ruslan
James, Joel
McClain, Nolan
Tofovic, Stevan P.
Rafikova, Olga
Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension
title Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension
title_full Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension
title_fullStr Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension
title_full_unstemmed Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension
title_short Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension
title_sort role of gender in regulation of redox homeostasis in pulmonary arterial hypertension
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562572/
https://www.ncbi.nlm.nih.gov/pubmed/31100969
http://dx.doi.org/10.3390/antiox8050135
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