Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review

An excessive requirement for methionine (MET), termed MET dependence, appears to be a general metabolic defect in cancer and has been shown to be a very effective therapeutic target. MET restriction (MR) has inhibited the growth of all major cancer types by selectively arresting cancer cells in the...

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Autores principales: Kawaguchi, Kei, Han, Qinghong, Li, Shukuan, Tan, Yuying, Igarashi, Kentaro, Murakami, Takashi, Unno, Michiaki, Hoffman, Robert M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562625/
https://www.ncbi.nlm.nih.gov/pubmed/31052611
http://dx.doi.org/10.3390/cells8050410
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author Kawaguchi, Kei
Han, Qinghong
Li, Shukuan
Tan, Yuying
Igarashi, Kentaro
Murakami, Takashi
Unno, Michiaki
Hoffman, Robert M.
author_facet Kawaguchi, Kei
Han, Qinghong
Li, Shukuan
Tan, Yuying
Igarashi, Kentaro
Murakami, Takashi
Unno, Michiaki
Hoffman, Robert M.
author_sort Kawaguchi, Kei
collection PubMed
description An excessive requirement for methionine (MET), termed MET dependence, appears to be a general metabolic defect in cancer and has been shown to be a very effective therapeutic target. MET restriction (MR) has inhibited the growth of all major cancer types by selectively arresting cancer cells in the late-S/G(2) phase, when they also become highly sensitive to cytotoxic agents. Recombinant methioninase (rMETase) has been developed to effect MR. The present review describes the efficacy of rMETase on patient-derived orthotopic xenograft (PDOX) models of recalcitrant cancer, including the surprising result that rMETase administrated orally can be highly effective.
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spelling pubmed-65626252019-06-17 Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review Kawaguchi, Kei Han, Qinghong Li, Shukuan Tan, Yuying Igarashi, Kentaro Murakami, Takashi Unno, Michiaki Hoffman, Robert M. Cells Review An excessive requirement for methionine (MET), termed MET dependence, appears to be a general metabolic defect in cancer and has been shown to be a very effective therapeutic target. MET restriction (MR) has inhibited the growth of all major cancer types by selectively arresting cancer cells in the late-S/G(2) phase, when they also become highly sensitive to cytotoxic agents. Recombinant methioninase (rMETase) has been developed to effect MR. The present review describes the efficacy of rMETase on patient-derived orthotopic xenograft (PDOX) models of recalcitrant cancer, including the surprising result that rMETase administrated orally can be highly effective. MDPI 2019-05-02 /pmc/articles/PMC6562625/ /pubmed/31052611 http://dx.doi.org/10.3390/cells8050410 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kawaguchi, Kei
Han, Qinghong
Li, Shukuan
Tan, Yuying
Igarashi, Kentaro
Murakami, Takashi
Unno, Michiaki
Hoffman, Robert M.
Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
title Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
title_full Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
title_fullStr Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
title_full_unstemmed Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
title_short Efficacy of Recombinant Methioninase (rMETase) on Recalcitrant Cancer Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models: A Review
title_sort efficacy of recombinant methioninase (rmetase) on recalcitrant cancer patient-derived orthotopic xenograft (pdox) mouse models: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562625/
https://www.ncbi.nlm.nih.gov/pubmed/31052611
http://dx.doi.org/10.3390/cells8050410
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