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The Vicious Cross-Talk between Tumor Cells with an EMT Phenotype and Cells of the Immune System
Carcinoma cells that undergo an epithelial-mesenchymal transition (EMT) and display a predominantly mesenchymal phenotype (hereafter EMT tumor cells) are associated with immune exclusion and immune deviation in the tumor microenvironment (TME). A large body of evidence has shown that EMT tumor cells...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562673/ https://www.ncbi.nlm.nih.gov/pubmed/31096701 http://dx.doi.org/10.3390/cells8050460 |
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author | Romeo, Elisabetta Caserta, Carmelo Antonio Rumio, Cristiano Marcucci, Fabrizio |
author_facet | Romeo, Elisabetta Caserta, Carmelo Antonio Rumio, Cristiano Marcucci, Fabrizio |
author_sort | Romeo, Elisabetta |
collection | PubMed |
description | Carcinoma cells that undergo an epithelial-mesenchymal transition (EMT) and display a predominantly mesenchymal phenotype (hereafter EMT tumor cells) are associated with immune exclusion and immune deviation in the tumor microenvironment (TME). A large body of evidence has shown that EMT tumor cells and immune cells can reciprocally influence each other, with EMT cells promoting immune exclusion and deviation and immune cells promoting, under certain circumstances, the induction of EMT in tumor cells. This cross-talk between EMT tumor cells and immune cells can occur both between EMT tumor cells and cells of either the native or adaptive immune system. In this article, we review this evidence and the functional consequences of it. We also discuss some recent evidence showing that tumor cells and cells of the immune system respond to similar stimuli, activate the expression of partially overlapping gene sets, and acquire, at least in part, identical functionalities such as migration and invasion. The possible significance of these symmetrical changes in the cross-talk between EMT tumor cells and immune cells is addressed. Eventually, we also discuss possible therapeutic opportunities that may derive from disrupting this cross-talk. |
format | Online Article Text |
id | pubmed-6562673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65626732019-06-17 The Vicious Cross-Talk between Tumor Cells with an EMT Phenotype and Cells of the Immune System Romeo, Elisabetta Caserta, Carmelo Antonio Rumio, Cristiano Marcucci, Fabrizio Cells Review Carcinoma cells that undergo an epithelial-mesenchymal transition (EMT) and display a predominantly mesenchymal phenotype (hereafter EMT tumor cells) are associated with immune exclusion and immune deviation in the tumor microenvironment (TME). A large body of evidence has shown that EMT tumor cells and immune cells can reciprocally influence each other, with EMT cells promoting immune exclusion and deviation and immune cells promoting, under certain circumstances, the induction of EMT in tumor cells. This cross-talk between EMT tumor cells and immune cells can occur both between EMT tumor cells and cells of either the native or adaptive immune system. In this article, we review this evidence and the functional consequences of it. We also discuss some recent evidence showing that tumor cells and cells of the immune system respond to similar stimuli, activate the expression of partially overlapping gene sets, and acquire, at least in part, identical functionalities such as migration and invasion. The possible significance of these symmetrical changes in the cross-talk between EMT tumor cells and immune cells is addressed. Eventually, we also discuss possible therapeutic opportunities that may derive from disrupting this cross-talk. MDPI 2019-05-15 /pmc/articles/PMC6562673/ /pubmed/31096701 http://dx.doi.org/10.3390/cells8050460 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Romeo, Elisabetta Caserta, Carmelo Antonio Rumio, Cristiano Marcucci, Fabrizio The Vicious Cross-Talk between Tumor Cells with an EMT Phenotype and Cells of the Immune System |
title | The Vicious Cross-Talk between Tumor Cells with an EMT Phenotype and Cells of the Immune System |
title_full | The Vicious Cross-Talk between Tumor Cells with an EMT Phenotype and Cells of the Immune System |
title_fullStr | The Vicious Cross-Talk between Tumor Cells with an EMT Phenotype and Cells of the Immune System |
title_full_unstemmed | The Vicious Cross-Talk between Tumor Cells with an EMT Phenotype and Cells of the Immune System |
title_short | The Vicious Cross-Talk between Tumor Cells with an EMT Phenotype and Cells of the Immune System |
title_sort | vicious cross-talk between tumor cells with an emt phenotype and cells of the immune system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562673/ https://www.ncbi.nlm.nih.gov/pubmed/31096701 http://dx.doi.org/10.3390/cells8050460 |
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