Clinical, Virological Characteristics, and Outcomes of Treatment with Sofosbuvir/Ledipasvir in Two Pediatric Patients Infected by HCV Genotype 4

Direct-acting antiviral drugs to cure infections with Hepatitis C virus (HCV) achieve a sustained virological response (SVR) in more than 90% of adult patients. At present, clinical trials are ongoing and real-life data are still limited in children. Herein, we report two cases of pediatric patients...

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Autores principales: Marascio, Nadia, Mazzitelli, Maria, Pavia, Grazia, Giancotti, Aida, Barreca, Giorgio Settimo, Costa, Chiara, Pisani, Vincenzo, Greco, Giuseppe, Serapide, Francesca, Trecarichi, Enrico Maria, Casalinuovo, Francesco, Liberto, Maria Carla, Matera, Giovanni, Torti, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562692/
https://www.ncbi.nlm.nih.gov/pubmed/31060315
http://dx.doi.org/10.3390/cells8050416
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author Marascio, Nadia
Mazzitelli, Maria
Pavia, Grazia
Giancotti, Aida
Barreca, Giorgio Settimo
Costa, Chiara
Pisani, Vincenzo
Greco, Giuseppe
Serapide, Francesca
Trecarichi, Enrico Maria
Casalinuovo, Francesco
Liberto, Maria Carla
Matera, Giovanni
Torti, Carlo
author_facet Marascio, Nadia
Mazzitelli, Maria
Pavia, Grazia
Giancotti, Aida
Barreca, Giorgio Settimo
Costa, Chiara
Pisani, Vincenzo
Greco, Giuseppe
Serapide, Francesca
Trecarichi, Enrico Maria
Casalinuovo, Francesco
Liberto, Maria Carla
Matera, Giovanni
Torti, Carlo
author_sort Marascio, Nadia
collection PubMed
description Direct-acting antiviral drugs to cure infections with Hepatitis C virus (HCV) achieve a sustained virological response (SVR) in more than 90% of adult patients. At present, clinical trials are ongoing and real-life data are still limited in children. Herein, we report two cases of pediatric patients treated with fixed-dose combination of sofosbuvir/ledipasvir, already approved to treat HCV4 genotype. Both young girls achieved SVR even though HCV4 isolates carried L28M and M31L NS5A resistance-associated substitutions (RASs). Therefore, possible effects of these RASs merit further study, especially in children.
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spelling pubmed-65626922019-06-17 Clinical, Virological Characteristics, and Outcomes of Treatment with Sofosbuvir/Ledipasvir in Two Pediatric Patients Infected by HCV Genotype 4 Marascio, Nadia Mazzitelli, Maria Pavia, Grazia Giancotti, Aida Barreca, Giorgio Settimo Costa, Chiara Pisani, Vincenzo Greco, Giuseppe Serapide, Francesca Trecarichi, Enrico Maria Casalinuovo, Francesco Liberto, Maria Carla Matera, Giovanni Torti, Carlo Cells Case Report Direct-acting antiviral drugs to cure infections with Hepatitis C virus (HCV) achieve a sustained virological response (SVR) in more than 90% of adult patients. At present, clinical trials are ongoing and real-life data are still limited in children. Herein, we report two cases of pediatric patients treated with fixed-dose combination of sofosbuvir/ledipasvir, already approved to treat HCV4 genotype. Both young girls achieved SVR even though HCV4 isolates carried L28M and M31L NS5A resistance-associated substitutions (RASs). Therefore, possible effects of these RASs merit further study, especially in children. MDPI 2019-05-05 /pmc/articles/PMC6562692/ /pubmed/31060315 http://dx.doi.org/10.3390/cells8050416 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Marascio, Nadia
Mazzitelli, Maria
Pavia, Grazia
Giancotti, Aida
Barreca, Giorgio Settimo
Costa, Chiara
Pisani, Vincenzo
Greco, Giuseppe
Serapide, Francesca
Trecarichi, Enrico Maria
Casalinuovo, Francesco
Liberto, Maria Carla
Matera, Giovanni
Torti, Carlo
Clinical, Virological Characteristics, and Outcomes of Treatment with Sofosbuvir/Ledipasvir in Two Pediatric Patients Infected by HCV Genotype 4
title Clinical, Virological Characteristics, and Outcomes of Treatment with Sofosbuvir/Ledipasvir in Two Pediatric Patients Infected by HCV Genotype 4
title_full Clinical, Virological Characteristics, and Outcomes of Treatment with Sofosbuvir/Ledipasvir in Two Pediatric Patients Infected by HCV Genotype 4
title_fullStr Clinical, Virological Characteristics, and Outcomes of Treatment with Sofosbuvir/Ledipasvir in Two Pediatric Patients Infected by HCV Genotype 4
title_full_unstemmed Clinical, Virological Characteristics, and Outcomes of Treatment with Sofosbuvir/Ledipasvir in Two Pediatric Patients Infected by HCV Genotype 4
title_short Clinical, Virological Characteristics, and Outcomes of Treatment with Sofosbuvir/Ledipasvir in Two Pediatric Patients Infected by HCV Genotype 4
title_sort clinical, virological characteristics, and outcomes of treatment with sofosbuvir/ledipasvir in two pediatric patients infected by hcv genotype 4
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562692/
https://www.ncbi.nlm.nih.gov/pubmed/31060315
http://dx.doi.org/10.3390/cells8050416
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