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Stimulation of the Angular Gyrus Improves the Level of Consciousness

Background: Navigated repetitive transcranial magnetic stimulation (rTMS) is a promising tool for neuromodulation. In previous studies it has been shown that the activity of the default mode network (DMN) areas, particularly of its key region—the angular gyrus—is positively correlated with the level...

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Autores principales: Legostaeva, Liudmila, Poydasheva, Alexandra, Iazeva, Elizaveta, Sinitsyn, Dmitry, Sergeev, Dmitry, Bakulin, Ilya, Lagoda, Dmitry, Kremneva, Elena, Morozova, Sofya, Ryabinkina, Yulia, Suponeva, Natalia, Piradov, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562708/
https://www.ncbi.nlm.nih.gov/pubmed/31064138
http://dx.doi.org/10.3390/brainsci9050103
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author Legostaeva, Liudmila
Poydasheva, Alexandra
Iazeva, Elizaveta
Sinitsyn, Dmitry
Sergeev, Dmitry
Bakulin, Ilya
Lagoda, Dmitry
Kremneva, Elena
Morozova, Sofya
Ryabinkina, Yulia
Suponeva, Natalia
Piradov, Michael
author_facet Legostaeva, Liudmila
Poydasheva, Alexandra
Iazeva, Elizaveta
Sinitsyn, Dmitry
Sergeev, Dmitry
Bakulin, Ilya
Lagoda, Dmitry
Kremneva, Elena
Morozova, Sofya
Ryabinkina, Yulia
Suponeva, Natalia
Piradov, Michael
author_sort Legostaeva, Liudmila
collection PubMed
description Background: Navigated repetitive transcranial magnetic stimulation (rTMS) is a promising tool for neuromodulation. In previous studies it has been shown that the activity of the default mode network (DMN) areas, particularly of its key region—the angular gyrus—is positively correlated with the level of consciousness. Our study aimed to explore the effect of rTMS of the angular gyrus as a new approach for disorders of consciousness (DOC) treatment; Methods: A 10-session 2-week high-frequency rTMS protocol was delivered over the left angular gyrus in 38 DOC patients with repeated neurobehavioral assessments obtained at baseline and in 2 days after the stimulation course was complete; Results: 20 Hz-rTMS over left angular gyrus improved the coma recovery scale revised (CRS-R) total score in minimally conscious state (MCS) patients. We observed no effects in vegetative state (VS) patients; and Conclusions: The left angular gyrus is likely to be effective target for rTMS in patients with present signs of consciousness.
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spelling pubmed-65627082019-06-17 Stimulation of the Angular Gyrus Improves the Level of Consciousness Legostaeva, Liudmila Poydasheva, Alexandra Iazeva, Elizaveta Sinitsyn, Dmitry Sergeev, Dmitry Bakulin, Ilya Lagoda, Dmitry Kremneva, Elena Morozova, Sofya Ryabinkina, Yulia Suponeva, Natalia Piradov, Michael Brain Sci Article Background: Navigated repetitive transcranial magnetic stimulation (rTMS) is a promising tool for neuromodulation. In previous studies it has been shown that the activity of the default mode network (DMN) areas, particularly of its key region—the angular gyrus—is positively correlated with the level of consciousness. Our study aimed to explore the effect of rTMS of the angular gyrus as a new approach for disorders of consciousness (DOC) treatment; Methods: A 10-session 2-week high-frequency rTMS protocol was delivered over the left angular gyrus in 38 DOC patients with repeated neurobehavioral assessments obtained at baseline and in 2 days after the stimulation course was complete; Results: 20 Hz-rTMS over left angular gyrus improved the coma recovery scale revised (CRS-R) total score in minimally conscious state (MCS) patients. We observed no effects in vegetative state (VS) patients; and Conclusions: The left angular gyrus is likely to be effective target for rTMS in patients with present signs of consciousness. MDPI 2019-05-06 /pmc/articles/PMC6562708/ /pubmed/31064138 http://dx.doi.org/10.3390/brainsci9050103 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Legostaeva, Liudmila
Poydasheva, Alexandra
Iazeva, Elizaveta
Sinitsyn, Dmitry
Sergeev, Dmitry
Bakulin, Ilya
Lagoda, Dmitry
Kremneva, Elena
Morozova, Sofya
Ryabinkina, Yulia
Suponeva, Natalia
Piradov, Michael
Stimulation of the Angular Gyrus Improves the Level of Consciousness
title Stimulation of the Angular Gyrus Improves the Level of Consciousness
title_full Stimulation of the Angular Gyrus Improves the Level of Consciousness
title_fullStr Stimulation of the Angular Gyrus Improves the Level of Consciousness
title_full_unstemmed Stimulation of the Angular Gyrus Improves the Level of Consciousness
title_short Stimulation of the Angular Gyrus Improves the Level of Consciousness
title_sort stimulation of the angular gyrus improves the level of consciousness
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562708/
https://www.ncbi.nlm.nih.gov/pubmed/31064138
http://dx.doi.org/10.3390/brainsci9050103
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