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Development of a Spherical Model with a 3D Microchannel: An Application to Glaucoma Surgery

Three-dimensional (3D) microfluidic channels, which simulate human tissues such as blood vessels, are useful in surgical simulator models for evaluating surgical devices and training novice surgeons. However, animal models and current artificial models do not sufficiently mimic the anatomical and me...

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Autores principales: Gallab, Mahmoud, Omata, Seiji, Harada, Kanako, Mitsuishi, Mamoru, Sugimoto, Koichiro, Ueta, Takashi, Totsuka, Kiyohito, Araki, Fumiyuki, Takao, Muneyuki, Aihara, Makoto, Arai, Fumihito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562714/
https://www.ncbi.nlm.nih.gov/pubmed/31052324
http://dx.doi.org/10.3390/mi10050297
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author Gallab, Mahmoud
Omata, Seiji
Harada, Kanako
Mitsuishi, Mamoru
Sugimoto, Koichiro
Ueta, Takashi
Totsuka, Kiyohito
Araki, Fumiyuki
Takao, Muneyuki
Aihara, Makoto
Arai, Fumihito
author_facet Gallab, Mahmoud
Omata, Seiji
Harada, Kanako
Mitsuishi, Mamoru
Sugimoto, Koichiro
Ueta, Takashi
Totsuka, Kiyohito
Araki, Fumiyuki
Takao, Muneyuki
Aihara, Makoto
Arai, Fumihito
author_sort Gallab, Mahmoud
collection PubMed
description Three-dimensional (3D) microfluidic channels, which simulate human tissues such as blood vessels, are useful in surgical simulator models for evaluating surgical devices and training novice surgeons. However, animal models and current artificial models do not sufficiently mimic the anatomical and mechanical properties of human tissues. Therefore, we established a novel fabrication method to fabricate an eye model for use as a surgical simulator. For the glaucoma surgery task, the eye model consists of a sclera with a clear cornea; a 3D microchannel with a width of 200–500 µm, representing the Schlemm’s canal (SC); and a thin membrane with a thickness of 40–132 µm, representing the trabecular meshwork (TM). The sclera model with a clear cornea and SC was fabricated by 3D molding. Blow molding was used to fabricate the TM to cover the inner surface of the sclera part. Soft materials with controllable mechanical behaviors were used to fabricate the sclera and TM parts to mimic the mechanical properties of human tissues. Additionally, to simulate the surgery with constraints similar to those in a real operation, the eye model was installed on a skull platform. Therefore, in this paper, we propose an integration method for fabricating an eye model that has a 3D microchannel representing the SC and a membrane representing the TM, to develop a glaucoma model for training novice surgeons.
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spelling pubmed-65627142019-06-17 Development of a Spherical Model with a 3D Microchannel: An Application to Glaucoma Surgery Gallab, Mahmoud Omata, Seiji Harada, Kanako Mitsuishi, Mamoru Sugimoto, Koichiro Ueta, Takashi Totsuka, Kiyohito Araki, Fumiyuki Takao, Muneyuki Aihara, Makoto Arai, Fumihito Micromachines (Basel) Article Three-dimensional (3D) microfluidic channels, which simulate human tissues such as blood vessels, are useful in surgical simulator models for evaluating surgical devices and training novice surgeons. However, animal models and current artificial models do not sufficiently mimic the anatomical and mechanical properties of human tissues. Therefore, we established a novel fabrication method to fabricate an eye model for use as a surgical simulator. For the glaucoma surgery task, the eye model consists of a sclera with a clear cornea; a 3D microchannel with a width of 200–500 µm, representing the Schlemm’s canal (SC); and a thin membrane with a thickness of 40–132 µm, representing the trabecular meshwork (TM). The sclera model with a clear cornea and SC was fabricated by 3D molding. Blow molding was used to fabricate the TM to cover the inner surface of the sclera part. Soft materials with controllable mechanical behaviors were used to fabricate the sclera and TM parts to mimic the mechanical properties of human tissues. Additionally, to simulate the surgery with constraints similar to those in a real operation, the eye model was installed on a skull platform. Therefore, in this paper, we propose an integration method for fabricating an eye model that has a 3D microchannel representing the SC and a membrane representing the TM, to develop a glaucoma model for training novice surgeons. MDPI 2019-04-30 /pmc/articles/PMC6562714/ /pubmed/31052324 http://dx.doi.org/10.3390/mi10050297 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gallab, Mahmoud
Omata, Seiji
Harada, Kanako
Mitsuishi, Mamoru
Sugimoto, Koichiro
Ueta, Takashi
Totsuka, Kiyohito
Araki, Fumiyuki
Takao, Muneyuki
Aihara, Makoto
Arai, Fumihito
Development of a Spherical Model with a 3D Microchannel: An Application to Glaucoma Surgery
title Development of a Spherical Model with a 3D Microchannel: An Application to Glaucoma Surgery
title_full Development of a Spherical Model with a 3D Microchannel: An Application to Glaucoma Surgery
title_fullStr Development of a Spherical Model with a 3D Microchannel: An Application to Glaucoma Surgery
title_full_unstemmed Development of a Spherical Model with a 3D Microchannel: An Application to Glaucoma Surgery
title_short Development of a Spherical Model with a 3D Microchannel: An Application to Glaucoma Surgery
title_sort development of a spherical model with a 3d microchannel: an application to glaucoma surgery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562714/
https://www.ncbi.nlm.nih.gov/pubmed/31052324
http://dx.doi.org/10.3390/mi10050297
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