Repurposing the Electron Transfer Reactant Phenazine Methosulfate (PMS) for the Apoptotic Elimination of Malignant Melanoma Cells through Induction of Lethal Oxidative and Mitochondriotoxic Stress

Redox-directed pharmacophores have shown potential for the apoptotic elimination of cancer cells through chemotherapeutic induction of oxidative stress. Phenazine methosulfate (PMS), a N-alkylphenazinium cation-based redox cycler, is used widely as an electron transfer reactant coupling NAD(P)H gene...

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Detalles Bibliográficos
Autores principales: Hua, Anh B., Justiniano, Rebecca, Perer, Jessica, Park, Sophia L., Li, Hui, Cabello, Christopher M., Wondrak, Georg T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562717/
https://www.ncbi.nlm.nih.gov/pubmed/31035569
http://dx.doi.org/10.3390/cancers11050590

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