Macrophages in Colorectal Cancer Liver Metastases

Tumor-associated macrophages (TAMs) provide a nurturing microenvironment for metastasis and are concomitantly key determinants of the efficacy of anticancer strategies. TAM represent an extremely heterogeneous population in terms of cell morphology, functions, and tissue localization. Colorectal liv...

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Autores principales: Cortese, Nina, Soldani, Cristiana, Franceschini, Barbara, Barbagallo, Marialuisa, Marchesi, Federica, Torzilli, Guido, Donadon, Matteo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562719/
https://www.ncbi.nlm.nih.gov/pubmed/31067629
http://dx.doi.org/10.3390/cancers11050633
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author Cortese, Nina
Soldani, Cristiana
Franceschini, Barbara
Barbagallo, Marialuisa
Marchesi, Federica
Torzilli, Guido
Donadon, Matteo
author_facet Cortese, Nina
Soldani, Cristiana
Franceschini, Barbara
Barbagallo, Marialuisa
Marchesi, Federica
Torzilli, Guido
Donadon, Matteo
author_sort Cortese, Nina
collection PubMed
description Tumor-associated macrophages (TAMs) provide a nurturing microenvironment for metastasis and are concomitantly key determinants of the efficacy of anticancer strategies. TAM represent an extremely heterogeneous population in terms of cell morphology, functions, and tissue localization. Colorectal liver metastases (CLM) display a high heterogeneity, responsible for a wide array of clinical presentations and responsiveness to treatments. In the era of precision medicine, there is a critical need of reliable prognostic markers to improve patient stratification, and, for their predominance in metastatic tissues, TAMs are emerging as promising candidates.
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spelling pubmed-65627192019-06-17 Macrophages in Colorectal Cancer Liver Metastases Cortese, Nina Soldani, Cristiana Franceschini, Barbara Barbagallo, Marialuisa Marchesi, Federica Torzilli, Guido Donadon, Matteo Cancers (Basel) Review Tumor-associated macrophages (TAMs) provide a nurturing microenvironment for metastasis and are concomitantly key determinants of the efficacy of anticancer strategies. TAM represent an extremely heterogeneous population in terms of cell morphology, functions, and tissue localization. Colorectal liver metastases (CLM) display a high heterogeneity, responsible for a wide array of clinical presentations and responsiveness to treatments. In the era of precision medicine, there is a critical need of reliable prognostic markers to improve patient stratification, and, for their predominance in metastatic tissues, TAMs are emerging as promising candidates. MDPI 2019-05-07 /pmc/articles/PMC6562719/ /pubmed/31067629 http://dx.doi.org/10.3390/cancers11050633 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cortese, Nina
Soldani, Cristiana
Franceschini, Barbara
Barbagallo, Marialuisa
Marchesi, Federica
Torzilli, Guido
Donadon, Matteo
Macrophages in Colorectal Cancer Liver Metastases
title Macrophages in Colorectal Cancer Liver Metastases
title_full Macrophages in Colorectal Cancer Liver Metastases
title_fullStr Macrophages in Colorectal Cancer Liver Metastases
title_full_unstemmed Macrophages in Colorectal Cancer Liver Metastases
title_short Macrophages in Colorectal Cancer Liver Metastases
title_sort macrophages in colorectal cancer liver metastases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562719/
https://www.ncbi.nlm.nih.gov/pubmed/31067629
http://dx.doi.org/10.3390/cancers11050633
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AT barbagallomarialuisa macrophagesincolorectalcancerlivermetastases
AT marchesifederica macrophagesincolorectalcancerlivermetastases
AT torzilliguido macrophagesincolorectalcancerlivermetastases
AT donadonmatteo macrophagesincolorectalcancerlivermetastases

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