Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease

The small GTPases of the Rho family regulate many aspects of actin dynamics, but are functionally connected to many other cellular processes. Rac1, a member of this family, besides its known function in the regulation of actin cytoskeleton, plays a key role in the production of reactive oxygen speci...

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Detalles Bibliográficos
Autores principales: Margiotta, Azzurra, Bucci, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562727/
https://www.ncbi.nlm.nih.gov/pubmed/31035701
http://dx.doi.org/10.3390/cells8050396
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author Margiotta, Azzurra
Bucci, Cecilia
author_facet Margiotta, Azzurra
Bucci, Cecilia
author_sort Margiotta, Azzurra
collection PubMed
description The small GTPases of the Rho family regulate many aspects of actin dynamics, but are functionally connected to many other cellular processes. Rac1, a member of this family, besides its known function in the regulation of actin cytoskeleton, plays a key role in the production of reactive oxygen species, in gene transcription, in DNA repair, and also has been proven to have specific roles in neurons. This review focuses on the cooperation between Rac1 and Rab proteins, analyzing how the coordination between these GTPases impact on cells and how alterations of their functions lead to disease.
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spelling pubmed-65627272019-06-17 Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease Margiotta, Azzurra Bucci, Cecilia Cells Review The small GTPases of the Rho family regulate many aspects of actin dynamics, but are functionally connected to many other cellular processes. Rac1, a member of this family, besides its known function in the regulation of actin cytoskeleton, plays a key role in the production of reactive oxygen species, in gene transcription, in DNA repair, and also has been proven to have specific roles in neurons. This review focuses on the cooperation between Rac1 and Rab proteins, analyzing how the coordination between these GTPases impact on cells and how alterations of their functions lead to disease. MDPI 2019-04-29 /pmc/articles/PMC6562727/ /pubmed/31035701 http://dx.doi.org/10.3390/cells8050396 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Margiotta, Azzurra
Bucci, Cecilia
Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease
title Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease
title_full Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease
title_fullStr Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease
title_full_unstemmed Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease
title_short Coordination between Rac1 and Rab Proteins: Functional Implications in Health and Disease
title_sort coordination between rac1 and rab proteins: functional implications in health and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562727/
https://www.ncbi.nlm.nih.gov/pubmed/31035701
http://dx.doi.org/10.3390/cells8050396
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