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RAC1 Takes the Lead in Solid Tumors

Three GTPases, RAC, RHO, and Cdc42, play essential roles in coordinating many cellular functions during embryonic development, both in healthy cells and in disease conditions like cancers. We have presented patterns of distribution of the frequency of RAC1-alteration(s) in cancers as obtained from c...

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Detalles Bibliográficos
Autores principales: De, Pradip, Aske, Jennifer Carlson, Dey, Nandini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562738/
https://www.ncbi.nlm.nih.gov/pubmed/31027363
http://dx.doi.org/10.3390/cells8050382
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author De, Pradip
Aske, Jennifer Carlson
Dey, Nandini
author_facet De, Pradip
Aske, Jennifer Carlson
Dey, Nandini
author_sort De, Pradip
collection PubMed
description Three GTPases, RAC, RHO, and Cdc42, play essential roles in coordinating many cellular functions during embryonic development, both in healthy cells and in disease conditions like cancers. We have presented patterns of distribution of the frequency of RAC1-alteration(s) in cancers as obtained from cBioPortal. With this background data, we have interrogated the various functions of RAC1 in tumors, including proliferation, metastasis-associated phenotypes, and drug-resistance with a special emphasis on solid tumors in adults. We have reviewed the activation and regulation of RAC1 functions on the basis of its sub-cellular localization in tumor cells. Our review focuses on the role of RAC1 in cancers and summarizes the regulatory mechanisms, inhibitory efficacy, and the anticancer potential of RAC1-PAK targeting agents.
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spelling pubmed-65627382019-06-17 RAC1 Takes the Lead in Solid Tumors De, Pradip Aske, Jennifer Carlson Dey, Nandini Cells Review Three GTPases, RAC, RHO, and Cdc42, play essential roles in coordinating many cellular functions during embryonic development, both in healthy cells and in disease conditions like cancers. We have presented patterns of distribution of the frequency of RAC1-alteration(s) in cancers as obtained from cBioPortal. With this background data, we have interrogated the various functions of RAC1 in tumors, including proliferation, metastasis-associated phenotypes, and drug-resistance with a special emphasis on solid tumors in adults. We have reviewed the activation and regulation of RAC1 functions on the basis of its sub-cellular localization in tumor cells. Our review focuses on the role of RAC1 in cancers and summarizes the regulatory mechanisms, inhibitory efficacy, and the anticancer potential of RAC1-PAK targeting agents. MDPI 2019-04-26 /pmc/articles/PMC6562738/ /pubmed/31027363 http://dx.doi.org/10.3390/cells8050382 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
De, Pradip
Aske, Jennifer Carlson
Dey, Nandini
RAC1 Takes the Lead in Solid Tumors
title RAC1 Takes the Lead in Solid Tumors
title_full RAC1 Takes the Lead in Solid Tumors
title_fullStr RAC1 Takes the Lead in Solid Tumors
title_full_unstemmed RAC1 Takes the Lead in Solid Tumors
title_short RAC1 Takes the Lead in Solid Tumors
title_sort rac1 takes the lead in solid tumors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562738/
https://www.ncbi.nlm.nih.gov/pubmed/31027363
http://dx.doi.org/10.3390/cells8050382
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