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Overexpression of HMGA1 Figures as a Potential Prognostic Factor in Endometrioid Endometrial Carcinoma (EEC)

Endometrioid endometrial carcinomas (EEC) are the most common malignant gynecologic tumors. Despite the increase in EEC molecular knowledge, the identification of new biomarkers involved in disease’s development and/or progression would represent an improvement in its course. High-mobility group A p...

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Autores principales: Palumbo Júnior, Antonio, de Sousa, Vanessa Paiva Leite, Esposito, Francesco, De Martino, Marco, Forzati, Floriana, Moreira, Fábio Carvalho de Barros, Simão, Tatiana de Almeida, Nasciutti, Luiz Eurico, Fusco, Alfredo, Ribeiro Pinto, Luis Felipe, Bessa Pereira Chaves, Cláudia, Meireles Da Costa, Nathalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562754/
https://www.ncbi.nlm.nih.gov/pubmed/31096664
http://dx.doi.org/10.3390/genes10050372
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author Palumbo Júnior, Antonio
de Sousa, Vanessa Paiva Leite
Esposito, Francesco
De Martino, Marco
Forzati, Floriana
Moreira, Fábio Carvalho de Barros
Simão, Tatiana de Almeida
Nasciutti, Luiz Eurico
Fusco, Alfredo
Ribeiro Pinto, Luis Felipe
Bessa Pereira Chaves, Cláudia
Meireles Da Costa, Nathalia
author_facet Palumbo Júnior, Antonio
de Sousa, Vanessa Paiva Leite
Esposito, Francesco
De Martino, Marco
Forzati, Floriana
Moreira, Fábio Carvalho de Barros
Simão, Tatiana de Almeida
Nasciutti, Luiz Eurico
Fusco, Alfredo
Ribeiro Pinto, Luis Felipe
Bessa Pereira Chaves, Cláudia
Meireles Da Costa, Nathalia
author_sort Palumbo Júnior, Antonio
collection PubMed
description Endometrioid endometrial carcinomas (EEC) are the most common malignant gynecologic tumors. Despite the increase in EEC molecular knowledge, the identification of new biomarkers involved in disease’s development and/or progression would represent an improvement in its course. High-mobility group A protein (HMGA) family members are frequently overexpressed in a wide range of malignancies, correlating with a poor prognosis. Thus, the aim of this study was to analyze HMGA1 and HMGA2 expression pattern and their potential role as EEC biomarkers. HMGA1 and HMGA2 expression was initially evaluated in a series of 46 EEC tumors (stages IA to IV), and the findings were then validated in The Cancer Genome Atlas (TCGA) EEC cohort, comprising 381 EEC tumors (stages IA to IV). Our results reveal that HMGA1 and HMGA2 mRNA and protein are overexpressed in ECC, but only HMGA1 expression is associated with increased histological grade and tumor size. Moreover, HMGA1 but not HMGA2 overexpression was identified as a negative prognostic factor to EEC patients. Finally, a positive correlation between expression of HMGA1 pseudogenes—HMGA1-P6 and HMGA1-P7—and HMGA1 itself was detected, suggesting HMGA1 pseudogenes may play a role in HMGA1 expression regulation in EEC. Thus, these results indicate that HMGA1 overexpression possesses a potential role as a prognostic biomarker for EEC.
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spelling pubmed-65627542019-06-17 Overexpression of HMGA1 Figures as a Potential Prognostic Factor in Endometrioid Endometrial Carcinoma (EEC) Palumbo Júnior, Antonio de Sousa, Vanessa Paiva Leite Esposito, Francesco De Martino, Marco Forzati, Floriana Moreira, Fábio Carvalho de Barros Simão, Tatiana de Almeida Nasciutti, Luiz Eurico Fusco, Alfredo Ribeiro Pinto, Luis Felipe Bessa Pereira Chaves, Cláudia Meireles Da Costa, Nathalia Genes (Basel) Article Endometrioid endometrial carcinomas (EEC) are the most common malignant gynecologic tumors. Despite the increase in EEC molecular knowledge, the identification of new biomarkers involved in disease’s development and/or progression would represent an improvement in its course. High-mobility group A protein (HMGA) family members are frequently overexpressed in a wide range of malignancies, correlating with a poor prognosis. Thus, the aim of this study was to analyze HMGA1 and HMGA2 expression pattern and their potential role as EEC biomarkers. HMGA1 and HMGA2 expression was initially evaluated in a series of 46 EEC tumors (stages IA to IV), and the findings were then validated in The Cancer Genome Atlas (TCGA) EEC cohort, comprising 381 EEC tumors (stages IA to IV). Our results reveal that HMGA1 and HMGA2 mRNA and protein are overexpressed in ECC, but only HMGA1 expression is associated with increased histological grade and tumor size. Moreover, HMGA1 but not HMGA2 overexpression was identified as a negative prognostic factor to EEC patients. Finally, a positive correlation between expression of HMGA1 pseudogenes—HMGA1-P6 and HMGA1-P7—and HMGA1 itself was detected, suggesting HMGA1 pseudogenes may play a role in HMGA1 expression regulation in EEC. Thus, these results indicate that HMGA1 overexpression possesses a potential role as a prognostic biomarker for EEC. MDPI 2019-05-15 /pmc/articles/PMC6562754/ /pubmed/31096664 http://dx.doi.org/10.3390/genes10050372 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Palumbo Júnior, Antonio
de Sousa, Vanessa Paiva Leite
Esposito, Francesco
De Martino, Marco
Forzati, Floriana
Moreira, Fábio Carvalho de Barros
Simão, Tatiana de Almeida
Nasciutti, Luiz Eurico
Fusco, Alfredo
Ribeiro Pinto, Luis Felipe
Bessa Pereira Chaves, Cláudia
Meireles Da Costa, Nathalia
Overexpression of HMGA1 Figures as a Potential Prognostic Factor in Endometrioid Endometrial Carcinoma (EEC)
title Overexpression of HMGA1 Figures as a Potential Prognostic Factor in Endometrioid Endometrial Carcinoma (EEC)
title_full Overexpression of HMGA1 Figures as a Potential Prognostic Factor in Endometrioid Endometrial Carcinoma (EEC)
title_fullStr Overexpression of HMGA1 Figures as a Potential Prognostic Factor in Endometrioid Endometrial Carcinoma (EEC)
title_full_unstemmed Overexpression of HMGA1 Figures as a Potential Prognostic Factor in Endometrioid Endometrial Carcinoma (EEC)
title_short Overexpression of HMGA1 Figures as a Potential Prognostic Factor in Endometrioid Endometrial Carcinoma (EEC)
title_sort overexpression of hmga1 figures as a potential prognostic factor in endometrioid endometrial carcinoma (eec)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562754/
https://www.ncbi.nlm.nih.gov/pubmed/31096664
http://dx.doi.org/10.3390/genes10050372
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