Histone H3 Mutations: An Updated View of Their Role in Chromatin Deregulation and Cancer

In this review, we describe the attributes of histone H3 mutants identified in cancer. H3 mutants were first identified in genes encoding H3.3, in pediatric high-grade glioma, and subsequently in chondrosarcomas and giant cell tumors of bone (GCTB) in adolescents. The most heavily studied are the ly...

Descripción completa

Detalles Bibliográficos
Autores principales: Lowe, Brandon R., Maxham, Lily A., Hamey, Joshua J., Wilkins, Marc R., Partridge, Janet F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562757/
https://www.ncbi.nlm.nih.gov/pubmed/31086012
http://dx.doi.org/10.3390/cancers11050660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562757/
https://www.ncbi.nlm.nih.gov/pubmed/31086012
http://dx.doi.org/10.3390/cancers11050660

Ejemplares similares