Cargando…

Novel Characterization of Antioxidant Enzyme, 3-Mercaptopyruvate Sulfurtransferase-Knockout Mice: Overexpression of the Evolutionarily-Related Enzyme Rhodanese

The antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase (MST, EC 2.8.1.2) is localized in the cytosol and mitochondria, while the evolutionarily-related enzyme, rhodanese (thiosulfate sulfurtransferase, TST, EC 2.8.1.1) is localized in the mitochondria. Recently, both enzymes have been shown to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nagahara, Noriyuki, Tanaka, Mio, Tanaka, Yukichi, Ito, Takaaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562775/ https://www.ncbi.nlm.nih.gov/pubmed/31052467 http://dx.doi.org/10.3390/antiox8050116

Ejemplares similares

Expression of 3-Mercaptopyruvate Sulfurtransferase in the Mouse
por: Tomita, Masahiro, et al.
Publicado: (2016)

Antioxidant enzyme, 3-mercaptopyruvate sulfurtransferase-knockout mice exhibit increased anxiety-like behaviors: a model for human mercaptolactate-cysteine disulfiduria
por: Nagahara, Noriyuki, et al.
Publicado: (2013)

Activation of 3-Mercaptopyruvate Sulfurtransferase by Glutaredoxin Reducing System
por: Nagahara, Noriyuki
Publicado: (2020)

The Expression and Activity of Rhodanese, 3-Mercaptopyruvate Sulfurtransferase, Cystathionine γ-Lyase in the Most Frequently Chosen Cellular Research Models
por: Kaczor-Kamińska, Marta, et al.
Publicado: (2021)

Catalytic Site Cysteines of Thiol Enzyme: Sulfurtransferases
por: Nagahara, Noriyuki
Publicado: (2011)

Identification of H(2)S(3) and H(2)S produced by 3-mercaptopyruvate sulfurtransferase in the brain
por: Kimura, Yuka, et al.
Publicado: (2015)

Role of 3-Mercaptopyruvate Sulfurtransferase (3-MST) in Physiology and Disease
por: Rao, Swetha Pavani, et al.
Publicado: (2023)

Differential Roles of Cystathionine Gamma-Lyase and Mercaptopyruvate Sulfurtransferase in Hapten-Induced Colitis and Contact Dermatitis in Mice
por: Akahoshi, Noriyuki, et al.
Publicado: (2023)

The protective role of the 3-mercaptopyruvate sulfurtransferase (3-MST)-hydrogen sulfide (H(2)S) pathway against experimental osteoarthritis
por: Nasi, Sonia, et al.
Publicado: (2020)

Arabidopsis thaliana 3-mercaptopyruvate sulfurtransferases interact with and are protected by reducing systems
por: Moseler, Anna, et al.
Publicado: (2021)

Inhibition of the 3-mercaptopyruvate sulfurtransferase—hydrogen sulfide system promotes cellular lipid accumulation
por: Casili, Giovanna, et al.
Publicado: (2022)

Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase
por: Ahmad, Akbar, et al.
Publicado: (2016)

Discovery and Mechanistic Characterization of Selective Inhibitors of H(2)S-producing Enzyme: 3-Mercaptopyruvate Sulfurtransferase (3MST) Targeting Active-site Cysteine Persulfide
por: Hanaoka, Kenjiro, et al.
Publicado: (2017)

Brain 3-Mercaptopyruvate Sulfurtransferase (3MST): Cellular Localization and Downregulation after Acute Stroke
por: Zhao, Heng, et al.
Publicado: (2013)

Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics in Murine Colon Cancer Cells
por: Augsburger, Fiona, et al.
Publicado: (2020)

Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts
por: Panagaki, Theodora, et al.
Publicado: (2020)

Role of Hydrogen Sulfide and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of the Endoplasmic Reticulum Stress Response in Hepatocytes
por: Panagaki, Theodora, et al.
Publicado: (2020)

Regulation of CyR61 expression and release by 3-mercaptopyruvate sulfurtransferase in colon cancer cells
por: Ascenção, Kelly, et al.
Publicado: (2022)

Increased Urinary 3-Mercaptolactate Excretion and Enhanced Passive Systemic Anaphylaxis in Mice Lacking Mercaptopyruvate Sulfurtransferase, a Model of Mercaptolactate-Cysteine Disulfiduria
por: Akahoshi, Noriyuki, et al.
Publicado: (2020)

N-Acetylcysteine Serves as Substrate of 3-Mercaptopyruvate Sulfurtransferase and Stimulates Sulfide Metabolism in Colon Cancer Cells
por: Zuhra, Karim, et al.
Publicado: (2019)

Sulfanegen stimulates 3-mercaptopyruvate sulfurtransferase activity and ameliorates Alzheimer's disease pathology and oxidative stress in vivo
por: Rao, Swetha Pavani, et al.
Publicado: (2022)

Fatty acids promote fatty liver disease via the dysregulation of 3-mercaptopyruvate sulfurtransferase/hydrogen sulfide pathway
por: Li, Meng, et al.
Publicado: (2018)

Cysteine Aminotransferase (CAT): A Pivotal Sponsor in Metabolic Remodeling and an Ally of 3-Mercaptopyruvate Sulfurtransferase (MST) in Cancer
por: Hipólito, Ana, et al.
Publicado: (2020)

Molecular cloning of rhodanese gene from soil metagenome of cold desert of North-West Himalayas: sequence and structural features of the rhodanese enzyme
por: Bhat, Archana, et al.
Publicado: (2014)

Role of Cystathionine β-Synthase and 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation, Migration, and Bioenergetics of Murine Breast Cancer Cells
por: Santos, Sidneia Sousa, et al.
Publicado: (2023)

Mycobacterium tuberculosis CysA2 is a dual sulfurtransferase with activity against thiosulfate and 3-mercaptopyruvate and interacts with mammalian cells
por: Meza, A. N., et al.
Publicado: (2019)

Effect of S-Allyl –L-Cysteine on MCF-7 Cell Line 3-Mercaptopyruvate Sulfurtransferase/Sulfane Sulfur System, Viability and Apoptosis
por: Bronowicka-Adamska, Patrycja, et al.
Publicado: (2020)

In silico screening, molecular dynamic simulations, and in vitro activity of selected natural compounds as an inhibitor of Leishmania donovani 3-mercaptopyruvate sulfurtransferase
por: Kant, Vishnu, et al.
Publicado: (2022)

3-Mercaptopyruvate Sulfurtransferase, Not Cystathionine β-Synthase Nor Cystathionine γ-Lyase, Mediates Hypoxia-Induced Migration of Vascular Endothelial Cells
por: Tao, Beibei, et al.
Publicado: (2017)

Hydrogen Sulfide From Cysteine Desulfurase, Not 3-Mercaptopyruvate Sulfurtransferase, Contributes to Sustaining Cell Growth and Bioenergetics in E. coli Under Anaerobic Conditions
por: Wang, Jun, et al.
Publicado: (2019)

The Human Mercaptopyruvate Sulfurtransferase TUM1 Is Involved in Moco Biosynthesis, Cytosolic tRNA Thiolation and Cellular Bioenergetics in Human Embryonic Kidney Cells
por: Ogunkola, Moses Olalekan, et al.
Publicado: (2023)

Thiosulfate-Cyanide Sulfurtransferase a Mitochondrial Essential Enzyme: From Cell Metabolism to the Biotechnological Applications
por: Buonvino, Silvia, et al.
Publicado: (2022)

The overexpression of major antioxidant enzymes does not extend the lifespan of mice
por: Pérez, Viviana I, et al.
Publicado: (2009)

Altered expression of antioxidant enzymes and autophagic proteins in transglutaminase 2 knockout mice
por: D’Orio, Barbara, et al.
Publicado: (2013)

MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity
por: Katsouda, Antonia, et al.
Publicado: (2022)

3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H(2)S(2), H(2)S(3) and H(2)S
por: Kimura, Yuka, et al.
Publicado: (2017)

H(2)S, Polysulfides, and Enzymes: Physiological and Pathological Aspects
por: Nagahara, Noriyuki, et al.
Publicado: (2020)

Evolutionarily Conserved Substrate Substructures for Automated Annotation of Enzyme Superfamilies
por: Chiang, Ranyee A., et al.
Publicado: (2008)

Evolutionarily Conserved Linkage between Enzyme Fold, Flexibility, and Catalysis
por: Ramanathan, Arvind, et al.
Publicado: (2011)

Molecular identification and characterization of rhodaneses from the insect herbivore Pieris rapae
por: Steiner, Anna-Maria, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ct5k76i9vhs08511rlm5ml72o5