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Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues

Chorioallantoic membrane assay (CAM assay) using fertilized chicken eggs has been used for the study of tumor formation, angiogenesis and metastasis. Recently, there is growing realization that this system provides a valuable assay for a patient-derived tumor model. Several reports establish that tu...

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Autores principales: Komatsu, Aoi, Matsumoto, Kotaro, Saito, Tomoki, Muto, Manabu, Tamanoi, Fuyuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562823/
https://www.ncbi.nlm.nih.gov/pubmed/31083409
http://dx.doi.org/10.3390/cells8050440
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author Komatsu, Aoi
Matsumoto, Kotaro
Saito, Tomoki
Muto, Manabu
Tamanoi, Fuyuhiko
author_facet Komatsu, Aoi
Matsumoto, Kotaro
Saito, Tomoki
Muto, Manabu
Tamanoi, Fuyuhiko
author_sort Komatsu, Aoi
collection PubMed
description Chorioallantoic membrane assay (CAM assay) using fertilized chicken eggs has been used for the study of tumor formation, angiogenesis and metastasis. Recently, there is growing realization that this system provides a valuable assay for a patient-derived tumor model. Several reports establish that tumor samples from cancer patients can be used to reproduce tumor in the chicken egg. High transplantation efficiency has been achieved. In this review, we discuss examples of transplanting patient tumors. We then discuss critical issues that need to be addressed to pursue this line of experiments. The patient-derived chicken egg model (PDcE model) has an advantage over other models in its rapid tumor formation. This raises the possibility that the PDcE model is valuable for identifying optimum drug for each individual patient.
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spelling pubmed-65628232019-06-17 Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues Komatsu, Aoi Matsumoto, Kotaro Saito, Tomoki Muto, Manabu Tamanoi, Fuyuhiko Cells Review Chorioallantoic membrane assay (CAM assay) using fertilized chicken eggs has been used for the study of tumor formation, angiogenesis and metastasis. Recently, there is growing realization that this system provides a valuable assay for a patient-derived tumor model. Several reports establish that tumor samples from cancer patients can be used to reproduce tumor in the chicken egg. High transplantation efficiency has been achieved. In this review, we discuss examples of transplanting patient tumors. We then discuss critical issues that need to be addressed to pursue this line of experiments. The patient-derived chicken egg model (PDcE model) has an advantage over other models in its rapid tumor formation. This raises the possibility that the PDcE model is valuable for identifying optimum drug for each individual patient. MDPI 2019-05-10 /pmc/articles/PMC6562823/ /pubmed/31083409 http://dx.doi.org/10.3390/cells8050440 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Komatsu, Aoi
Matsumoto, Kotaro
Saito, Tomoki
Muto, Manabu
Tamanoi, Fuyuhiko
Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues
title Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues
title_full Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues
title_fullStr Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues
title_full_unstemmed Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues
title_short Patient Derived Chicken Egg Tumor Model (PDcE Model): Current Status and Critical Issues
title_sort patient derived chicken egg tumor model (pdce model): current status and critical issues
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562823/
https://www.ncbi.nlm.nih.gov/pubmed/31083409
http://dx.doi.org/10.3390/cells8050440
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