Cargando…

Marine-Steroid Derivative 5α-Androst-3β, 5α, 6β-triol Protects Retinal Ganglion Cells from Ischemia–Reperfusion Injury by Activating Nrf2 Pathway

High intraocular pressure (IOP)-induced retinal ischemia leads to acute glaucoma, which is one of the leading causes of irreversible visual-field loss, characterized by loss of retinal ganglion cells (RGCs) and axonal injury in optic nerves (ONs). Oxidative stress and the inflammatory response play...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sheng, Longxiang, Lu, Bingzheng, Chen, Hui, Du, Yun, Chen, Chen, Cai, Wei, Yang, Yang, Tian, Xuyan, Huang, Zhaofeng, Chi, Wei, Lin, Suizhen, Yan, Guangmei, Yin, Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562834/ https://www.ncbi.nlm.nih.gov/pubmed/31060323 http://dx.doi.org/10.3390/md17050267

Ejemplares similares

5α-Androst-3-en-17β-yl acetate
por: Andrade, L. C. R., et al.
Publicado: (2009)

17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson's Disease
por: Nicoletti, Ferdinando, et al.
Publicado: (2012)

A Novel Synthetic Steroid of 2β,3α,5α-Trihydroxy-androst-6-one Alleviates the Loss of Rat Retinal Ganglion Cells Caused by Acute Intraocular Hypertension via Inhibiting the Inflammatory Activation of Microglia
por: Sun, Hong-Jia-Qi, et al.
Publicado: (2019)

Cholestane-3β, 5α, 6β-triol Suppresses Proliferation, Migration, and Invasion of Human Prostate Cancer Cells
por: Lin, Ching-Yu, et al.
Publicado: (2013)

2′-Methylpyrazolo[4′,3′:16,17]androst-5-en-3β-ol
por: Zheng, Hu-ling, et al.
Publicado: (2009)

Crystal structure of an epoxysterol: 9α,11α-epoxy-5α-cholest-7-ene-3β,5,6α-triol 3,6-diacetate
por: Piccialli, Vincenzo, et al.
Publicado: (2017)

Molecular Targets for 17α-Ethynyl-5-Androstene-3β,7β,17β-Triol, an Anti-Inflammatory Agent Derived from the Human Metabolome
por: Reading, Christopher L., et al.
Publicado: (2012)

Design, synthesis, and biological evaluation of novel androst-17β-amide structurally related compounds as dual 5α-reductase inhibitors and androgen receptor antagonists
por: Lao, Kejing, et al.
Publicado: (2019)

Olfactory perception of 5α-androst-16-en-3-one: Data obtained in the residents of central Russia
por: Klyuchnikova, Maria A., et al.
Publicado: (2022)

Development of an enzyme immunoassay to measure urinary and faecal 5α-androst-16-en-3-one in pigs
por: Kumar, Vinod, et al.
Publicado: (2023)

11α,15α-Dihydroxyandrost-4-ene-3,17-dione
por: Shen, Yan-Bing, et al.
Publicado: (2011)

16α,17α-Epoxy-17β-(1H-imidazol-1-yl)androst-4-en-3-one monohydrate
por: Anitha, A. G., et al.
Publicado: (2012)

Synthesis and biological evaluation of (20S,24R)-epoxy-dammarane-3β,12β,25-triol derivatives as α-glucosidase and PTP1B inhibitors
por: Yang, Xiao-Tong, et al.
Publicado: (2022)

The Effect of Effort Test on the Levels of Ischemia Modified Albumin, 7-ketocholesterol and Cholestan-3β , 5α , 6β -triol and their Role in the Diagnosis of Coronary Artery Disease
por: Keles, Muhammed Emin, et al.
Publicado: (2019)

SMARCB1 Promotes Ubiquitination and Degradation of NR4A3 via Direct Interaction Driven by ROS in Vascular Endothelial Cell Injury
por: Lu, Bingzheng, et al.
Publicado: (2020)

Use of Trifluoro-Acetate Derivatives for GC-MS and GC-MS/MS Quantification of Trace Amounts of Stera-3β,5α,6β-Triols (Tracers of Δ(5)-Sterol Autoxidation) in Environmental Samples
por: Aubert, Claude, et al.
Publicado: (2023)

5-Androstene-3β,7β,17β-triol (β-AET) Slows Thermal Injury Induced Osteopenia in Mice: Relation to Aging and Osteoporosis
por: Malik, Ajay K., et al.
Publicado: (2010)

A highly diastereoselective “super silyl” governed aldol reaction: synthesis of α,β-dioxyaldehydes and 1,2,3-triols
por: Gati, Wafa, et al.
Publicado: (2016)

Benzene-1,3,5-triol at 105 K
por: Görbitz, Carl Henrik, et al.
Publicado: (2008)

Experience during two generations of within lines boar performance testing, using 5α-androst-16-ene-3-one (5α-androstenone) and an olfactory judgement of boar taint
por: Jonsson, P, et al.
Publicado: (1979)

16α-Bromo-17β-hydroxy-5α-androstan-3β-yl acetate
por: Shi, Rui, et al.
Publicado: (2010)

1β,10α:4β,5α-Diepoxy-7αH-germacran-6β-ol monohydrate
por: He, Meng-Hui, et al.
Publicado: (2010)

Synthesis and In Vitro Antiproliferative Activity of Novel Androst-5-ene Triazolyl and Tetrazolyl Derivatives
por: Kádár, Zalán, et al.
Publicado: (2011)

Activation of the integrins α5β1 and αvβ3 and focal adhesion kinase (FAK) during arteriogenesis
por: Cai, Wei-Jun, et al.
Publicado: (2008)

Molecular determinants of αVβ5 localization in flat clathrin lattices – role of αVβ5 in cell adhesion and proliferation
por: Zuidema, Alba, et al.
Publicado: (2022)

The role of the nAChR subunits α5, β2, and β4 on synaptic transmission in the mouse superior cervical ganglion
por: Simeone, Xenia, et al.
Publicado: (2019)

Thionation of Some α,β-Unsaturated Steroidal Ketones
por: Krstić, Natalija M., et al.
Publicado: (2010)

Cell Transfection with a β-Cyclodextrin-PEI-Propane-1,2,3-Triol Nanopolymer
por: Lai, Wing-Fu, et al.
Publicado: (2014)

Effect of glutamate on lysosomal membrane permeabilization in primary cultured cortical neurons
por: YAN, MIN, et al.
Publicado: (2016)

Mena binds α5 integrin directly and modulates α5β1 function
por: Gupton, Stephanie L., et al.
Publicado: (2012)

Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links
por: González-Tarragó, Víctor, et al.
Publicado: (2017)

Investigation of cell cytotoxic activity and molecular mechanism of 5β,19-epoxycucurbita-6,23(E)-diene-3β,19(R),25-triol isolated from Momordica charantia on hepatoma cells
por: Yuan, Mei-Kang, et al.
Publicado: (2022)

N-tert-Butyl-5α-androstane-17β-carboxamide
por: Yan, Xin, et al.
Publicado: (2009)

3,5,7-Tripropyl-1-azaadamantane-4,6,10-triol
por: Saaidi, Pierre-Loïc, et al.
Publicado: (2008)

N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4
por: Hang, Qinglei, et al.
Publicado: (2016)

The α5 Nicotinic Acetylcholine Receptor Subunit Differentially Modulates α4β2(*) and α3β4(*) Receptors
por: Scholze, Petra, et al.
Publicado: (2020)

There is a world beyond αvβ3-integrin: Multimeric ligands for imaging of the integrin subtypes αvβ6, αvβ8, αvβ3, and α5β1 by positron emission tomography
por: Steiger, Katja, et al.
Publicado: (2021)

Matrix-regulated integrin α(v)β(5) maintains α(5)β(1)-dependent desmoplastic traits prognostic of neoplastic recurrence
por: Franco-Barraza, Janusz, et al.
Publicado: (2017)

Androstane-3β,5α,6β,17β-tetrol trihydrate
por: Andrade, L. C. R., et al.
Publicado: (2011)

Suppression of anoikis in human intestinal epithelial cells: differentiation state-selective roles of α2β1, α3β1, α5β1, and α6β4 integrins
por: Beauséjour, Marco, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_eearm731e11kn94j4934b6p5d9