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Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury

The aim of this article is to review the publications describing the use of mitochondria-targeted antioxidant therapy after traumatic brain injury (TBI). Recent works demonstrated that mitochondria-targeted antioxidants are very effective in reducing the negative effects associated with the developm...

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Autores principales: Stelmashook, Elena V., Isaev, Nickolay K., Genrikhs, Elisaveta E., Novikova, Svetlana V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562849/
https://www.ncbi.nlm.nih.gov/pubmed/31071926
http://dx.doi.org/10.3390/antiox8050124
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author Stelmashook, Elena V.
Isaev, Nickolay K.
Genrikhs, Elisaveta E.
Novikova, Svetlana V.
author_facet Stelmashook, Elena V.
Isaev, Nickolay K.
Genrikhs, Elisaveta E.
Novikova, Svetlana V.
author_sort Stelmashook, Elena V.
collection PubMed
description The aim of this article is to review the publications describing the use of mitochondria-targeted antioxidant therapy after traumatic brain injury (TBI). Recent works demonstrated that mitochondria-targeted antioxidants are very effective in reducing the negative effects associated with the development of secondary damage caused by TBI. Using various animal models of TBI, mitochondria-targeted antioxidants were shown to prevent cardiolipin oxidation in the brain and neuronal death, as well as to markedly reduce behavioral deficits and cortical lesion volume, brain water content, and DNA damage. In the future, not only a more detailed study of the mechanisms of action of various types of such antioxidants needs to be conducted, but also their therapeutic values and toxicological properties are to be determined. Moreover, the optimal therapeutic effect needs to be achieved in the shortest time possible from the onset of damage to the nervous tissue, since secondary brain damage in humans can develop for a long time, days and even months, depending on the severity of the damage.
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spelling pubmed-65628492019-06-17 Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury Stelmashook, Elena V. Isaev, Nickolay K. Genrikhs, Elisaveta E. Novikova, Svetlana V. Antioxidants (Basel) Perspective The aim of this article is to review the publications describing the use of mitochondria-targeted antioxidant therapy after traumatic brain injury (TBI). Recent works demonstrated that mitochondria-targeted antioxidants are very effective in reducing the negative effects associated with the development of secondary damage caused by TBI. Using various animal models of TBI, mitochondria-targeted antioxidants were shown to prevent cardiolipin oxidation in the brain and neuronal death, as well as to markedly reduce behavioral deficits and cortical lesion volume, brain water content, and DNA damage. In the future, not only a more detailed study of the mechanisms of action of various types of such antioxidants needs to be conducted, but also their therapeutic values and toxicological properties are to be determined. Moreover, the optimal therapeutic effect needs to be achieved in the shortest time possible from the onset of damage to the nervous tissue, since secondary brain damage in humans can develop for a long time, days and even months, depending on the severity of the damage. MDPI 2019-05-08 /pmc/articles/PMC6562849/ /pubmed/31071926 http://dx.doi.org/10.3390/antiox8050124 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Stelmashook, Elena V.
Isaev, Nickolay K.
Genrikhs, Elisaveta E.
Novikova, Svetlana V.
Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury
title Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury
title_full Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury
title_fullStr Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury
title_full_unstemmed Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury
title_short Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury
title_sort mitochondria-targeted antioxidants as potential therapy for the treatment of traumatic brain injury
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562849/
https://www.ncbi.nlm.nih.gov/pubmed/31071926
http://dx.doi.org/10.3390/antiox8050124
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