H3K18Ac as a Marker of Cancer Progression and Potential Target of Anti-Cancer Therapy

Acetylation and deacetylation are posttranslational modifications (PTMs) which affect the regulation of chromatin structure and its remodeling. Acetylation of histone 3 at lysine placed on position 18 (H3K18Ac) plays an important role in driving progression of many types of cancer, including breast,...

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Autores principales: Hałasa, Marta, Wawruszak, Anna, Przybyszewska, Alicja, Jaruga, Anna, Guz, Małgorzata, Kałafut, Joanna, Stepulak, Andrzej, Cybulski, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562857/
https://www.ncbi.nlm.nih.gov/pubmed/31121824
http://dx.doi.org/10.3390/cells8050485
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author Hałasa, Marta
Wawruszak, Anna
Przybyszewska, Alicja
Jaruga, Anna
Guz, Małgorzata
Kałafut, Joanna
Stepulak, Andrzej
Cybulski, Marek
author_facet Hałasa, Marta
Wawruszak, Anna
Przybyszewska, Alicja
Jaruga, Anna
Guz, Małgorzata
Kałafut, Joanna
Stepulak, Andrzej
Cybulski, Marek
author_sort Hałasa, Marta
collection PubMed
description Acetylation and deacetylation are posttranslational modifications (PTMs) which affect the regulation of chromatin structure and its remodeling. Acetylation of histone 3 at lysine placed on position 18 (H3K18Ac) plays an important role in driving progression of many types of cancer, including breast, colon, lung, hepatocellular, pancreatic, prostate, and thyroid cancer. The aim of this review is to analyze and discuss the newest findings regarding the role of H3K18Ac and acetylation of other histones in carcinogenesis. We summarize the level of H3K18Ac in different cancer cell lines and analyze its association with patients’ outcomes, including overall survival (OS), progression-free survival (PFS), and disease-free survival (DFS). Finally, we describe future perspectives of cancer therapeutic strategies based on H3K18 modifications.
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spelling pubmed-65628572019-06-17 H3K18Ac as a Marker of Cancer Progression and Potential Target of Anti-Cancer Therapy Hałasa, Marta Wawruszak, Anna Przybyszewska, Alicja Jaruga, Anna Guz, Małgorzata Kałafut, Joanna Stepulak, Andrzej Cybulski, Marek Cells Review Acetylation and deacetylation are posttranslational modifications (PTMs) which affect the regulation of chromatin structure and its remodeling. Acetylation of histone 3 at lysine placed on position 18 (H3K18Ac) plays an important role in driving progression of many types of cancer, including breast, colon, lung, hepatocellular, pancreatic, prostate, and thyroid cancer. The aim of this review is to analyze and discuss the newest findings regarding the role of H3K18Ac and acetylation of other histones in carcinogenesis. We summarize the level of H3K18Ac in different cancer cell lines and analyze its association with patients’ outcomes, including overall survival (OS), progression-free survival (PFS), and disease-free survival (DFS). Finally, we describe future perspectives of cancer therapeutic strategies based on H3K18 modifications. MDPI 2019-05-22 /pmc/articles/PMC6562857/ /pubmed/31121824 http://dx.doi.org/10.3390/cells8050485 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hałasa, Marta
Wawruszak, Anna
Przybyszewska, Alicja
Jaruga, Anna
Guz, Małgorzata
Kałafut, Joanna
Stepulak, Andrzej
Cybulski, Marek
H3K18Ac as a Marker of Cancer Progression and Potential Target of Anti-Cancer Therapy
title H3K18Ac as a Marker of Cancer Progression and Potential Target of Anti-Cancer Therapy
title_full H3K18Ac as a Marker of Cancer Progression and Potential Target of Anti-Cancer Therapy
title_fullStr H3K18Ac as a Marker of Cancer Progression and Potential Target of Anti-Cancer Therapy
title_full_unstemmed H3K18Ac as a Marker of Cancer Progression and Potential Target of Anti-Cancer Therapy
title_short H3K18Ac as a Marker of Cancer Progression and Potential Target of Anti-Cancer Therapy
title_sort h3k18ac as a marker of cancer progression and potential target of anti-cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562857/
https://www.ncbi.nlm.nih.gov/pubmed/31121824
http://dx.doi.org/10.3390/cells8050485
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