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Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin

Fucoxanthin (FX), a marine carotenoid found in macroalgae and microalgae, exhibits several beneficial effects to health. The anti-obesity activity of FX is well documented, but FX has not been mass-produced or applied extensively or commercially because of limited availability of raw materials and c...

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Autores principales: Koo, Song Yi, Hwang, Ji-Hyun, Yang, Seung-Hoon, Um, Jae-In, Hong, Kwang Won, Kang, Kyungsu, Pan, Cheol-Ho, Hwang, Keum Taek, Kim, Sang Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562887/
https://www.ncbi.nlm.nih.gov/pubmed/31137922
http://dx.doi.org/10.3390/md17050311
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author Koo, Song Yi
Hwang, Ji-Hyun
Yang, Seung-Hoon
Um, Jae-In
Hong, Kwang Won
Kang, Kyungsu
Pan, Cheol-Ho
Hwang, Keum Taek
Kim, Sang Min
author_facet Koo, Song Yi
Hwang, Ji-Hyun
Yang, Seung-Hoon
Um, Jae-In
Hong, Kwang Won
Kang, Kyungsu
Pan, Cheol-Ho
Hwang, Keum Taek
Kim, Sang Min
author_sort Koo, Song Yi
collection PubMed
description Fucoxanthin (FX), a marine carotenoid found in macroalgae and microalgae, exhibits several beneficial effects to health. The anti-obesity activity of FX is well documented, but FX has not been mass-produced or applied extensively or commercially because of limited availability of raw materials and complex extraction techniques. In this study, we investigated the anti-obesity effect of standardized FX powder (Phaeodactylum extract (PE)) developed from microalga Phaeodactylum tricornutum as a commercial functional food. The effects of PE on adipogenesis inhibition in 3T3-L1 adipocytes and anti-obesity in high-fat diet (HFD)-fed C57BL/6J mice were evaluated. PE and FX dose-dependently decreased intracellular lipid contents in adipocytes without cytotoxicity. In HFD-fed obese mice, PE supplementation for six weeks decreased body weight, organ weight, and adipocyte size. In the serum parameter analysis, the PE-treated groups showed attenuation of lipid metabolism dysfunction and liver damage induced by HFD. In the liver, uncoupling protein-1 (UCP1) upregulation and peroxisome proliferator activated receptor γ (PPARγ) downregulation were detected in the PE-treated groups. Additionally, micro computed tomography revealed lower fat accumulation in PE-treated groups compared to that in the HFD group. These results indicate that PE exerts anti-obesity effects by inhibiting adipocytic lipogenesis, inducing fat mass reduction and decreasing intracellular lipid content, adipocyte size, and adipose weight.
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spelling pubmed-65628872019-06-17 Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin Koo, Song Yi Hwang, Ji-Hyun Yang, Seung-Hoon Um, Jae-In Hong, Kwang Won Kang, Kyungsu Pan, Cheol-Ho Hwang, Keum Taek Kim, Sang Min Mar Drugs Article Fucoxanthin (FX), a marine carotenoid found in macroalgae and microalgae, exhibits several beneficial effects to health. The anti-obesity activity of FX is well documented, but FX has not been mass-produced or applied extensively or commercially because of limited availability of raw materials and complex extraction techniques. In this study, we investigated the anti-obesity effect of standardized FX powder (Phaeodactylum extract (PE)) developed from microalga Phaeodactylum tricornutum as a commercial functional food. The effects of PE on adipogenesis inhibition in 3T3-L1 adipocytes and anti-obesity in high-fat diet (HFD)-fed C57BL/6J mice were evaluated. PE and FX dose-dependently decreased intracellular lipid contents in adipocytes without cytotoxicity. In HFD-fed obese mice, PE supplementation for six weeks decreased body weight, organ weight, and adipocyte size. In the serum parameter analysis, the PE-treated groups showed attenuation of lipid metabolism dysfunction and liver damage induced by HFD. In the liver, uncoupling protein-1 (UCP1) upregulation and peroxisome proliferator activated receptor γ (PPARγ) downregulation were detected in the PE-treated groups. Additionally, micro computed tomography revealed lower fat accumulation in PE-treated groups compared to that in the HFD group. These results indicate that PE exerts anti-obesity effects by inhibiting adipocytic lipogenesis, inducing fat mass reduction and decreasing intracellular lipid content, adipocyte size, and adipose weight. MDPI 2019-05-27 /pmc/articles/PMC6562887/ /pubmed/31137922 http://dx.doi.org/10.3390/md17050311 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Koo, Song Yi
Hwang, Ji-Hyun
Yang, Seung-Hoon
Um, Jae-In
Hong, Kwang Won
Kang, Kyungsu
Pan, Cheol-Ho
Hwang, Keum Taek
Kim, Sang Min
Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin
title Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin
title_full Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin
title_fullStr Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin
title_full_unstemmed Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin
title_short Anti-Obesity Effect of Standardized Extract of Microalga Phaeodactylum tricornutum Containing Fucoxanthin
title_sort anti-obesity effect of standardized extract of microalga phaeodactylum tricornutum containing fucoxanthin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562887/
https://www.ncbi.nlm.nih.gov/pubmed/31137922
http://dx.doi.org/10.3390/md17050311
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