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Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection
As a typical biomedical detection task, nuclei detection has been widely used in human health management, disease diagnosis and other fields. However, the task of cell detection in microscopic images is still challenging because the nuclei are commonly small and dense with many overlapping nuclei in...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562946/ https://www.ncbi.nlm.nih.gov/pubmed/31126166 http://dx.doi.org/10.3390/cells8050499 |
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author | Wang, Eric Ke Zhang, Xun Pan, Leyun Cheng, Caixia Dimitrakopoulou-Strauss, Antonia Li, Yueping Zhe, Nie |
author_facet | Wang, Eric Ke Zhang, Xun Pan, Leyun Cheng, Caixia Dimitrakopoulou-Strauss, Antonia Li, Yueping Zhe, Nie |
author_sort | Wang, Eric Ke |
collection | PubMed |
description | As a typical biomedical detection task, nuclei detection has been widely used in human health management, disease diagnosis and other fields. However, the task of cell detection in microscopic images is still challenging because the nuclei are commonly small and dense with many overlapping nuclei in the images. In order to detect nuclei, the most important key step is to segment the cell targets accurately. Based on Mask RCNN model, we designed a multi-path dilated residual network, and realized a network structure to segment and detect dense small objects, and effectively solved the problem of information loss of small objects in deep neural network. The experimental results on two typical nuclear segmentation data sets show that our model has better recognition and segmentation capability for dense small targets. |
format | Online Article Text |
id | pubmed-6562946 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65629462019-06-17 Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection Wang, Eric Ke Zhang, Xun Pan, Leyun Cheng, Caixia Dimitrakopoulou-Strauss, Antonia Li, Yueping Zhe, Nie Cells Article As a typical biomedical detection task, nuclei detection has been widely used in human health management, disease diagnosis and other fields. However, the task of cell detection in microscopic images is still challenging because the nuclei are commonly small and dense with many overlapping nuclei in the images. In order to detect nuclei, the most important key step is to segment the cell targets accurately. Based on Mask RCNN model, we designed a multi-path dilated residual network, and realized a network structure to segment and detect dense small objects, and effectively solved the problem of information loss of small objects in deep neural network. The experimental results on two typical nuclear segmentation data sets show that our model has better recognition and segmentation capability for dense small targets. MDPI 2019-05-23 /pmc/articles/PMC6562946/ /pubmed/31126166 http://dx.doi.org/10.3390/cells8050499 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Wang, Eric Ke Zhang, Xun Pan, Leyun Cheng, Caixia Dimitrakopoulou-Strauss, Antonia Li, Yueping Zhe, Nie Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection |
title | Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection |
title_full | Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection |
title_fullStr | Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection |
title_full_unstemmed | Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection |
title_short | Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection |
title_sort | multi-path dilated residual network for nuclei segmentation and detection |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562946/ https://www.ncbi.nlm.nih.gov/pubmed/31126166 http://dx.doi.org/10.3390/cells8050499 |
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