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Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection

As a typical biomedical detection task, nuclei detection has been widely used in human health management, disease diagnosis and other fields. However, the task of cell detection in microscopic images is still challenging because the nuclei are commonly small and dense with many overlapping nuclei in...

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Autores principales: Wang, Eric Ke, Zhang, Xun, Pan, Leyun, Cheng, Caixia, Dimitrakopoulou-Strauss, Antonia, Li, Yueping, Zhe, Nie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562946/
https://www.ncbi.nlm.nih.gov/pubmed/31126166
http://dx.doi.org/10.3390/cells8050499
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author Wang, Eric Ke
Zhang, Xun
Pan, Leyun
Cheng, Caixia
Dimitrakopoulou-Strauss, Antonia
Li, Yueping
Zhe, Nie
author_facet Wang, Eric Ke
Zhang, Xun
Pan, Leyun
Cheng, Caixia
Dimitrakopoulou-Strauss, Antonia
Li, Yueping
Zhe, Nie
author_sort Wang, Eric Ke
collection PubMed
description As a typical biomedical detection task, nuclei detection has been widely used in human health management, disease diagnosis and other fields. However, the task of cell detection in microscopic images is still challenging because the nuclei are commonly small and dense with many overlapping nuclei in the images. In order to detect nuclei, the most important key step is to segment the cell targets accurately. Based on Mask RCNN model, we designed a multi-path dilated residual network, and realized a network structure to segment and detect dense small objects, and effectively solved the problem of information loss of small objects in deep neural network. The experimental results on two typical nuclear segmentation data sets show that our model has better recognition and segmentation capability for dense small targets.
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spelling pubmed-65629462019-06-17 Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection Wang, Eric Ke Zhang, Xun Pan, Leyun Cheng, Caixia Dimitrakopoulou-Strauss, Antonia Li, Yueping Zhe, Nie Cells Article As a typical biomedical detection task, nuclei detection has been widely used in human health management, disease diagnosis and other fields. However, the task of cell detection in microscopic images is still challenging because the nuclei are commonly small and dense with many overlapping nuclei in the images. In order to detect nuclei, the most important key step is to segment the cell targets accurately. Based on Mask RCNN model, we designed a multi-path dilated residual network, and realized a network structure to segment and detect dense small objects, and effectively solved the problem of information loss of small objects in deep neural network. The experimental results on two typical nuclear segmentation data sets show that our model has better recognition and segmentation capability for dense small targets. MDPI 2019-05-23 /pmc/articles/PMC6562946/ /pubmed/31126166 http://dx.doi.org/10.3390/cells8050499 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Eric Ke
Zhang, Xun
Pan, Leyun
Cheng, Caixia
Dimitrakopoulou-Strauss, Antonia
Li, Yueping
Zhe, Nie
Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection
title Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection
title_full Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection
title_fullStr Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection
title_full_unstemmed Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection
title_short Multi-Path Dilated Residual Network for Nuclei Segmentation and Detection
title_sort multi-path dilated residual network for nuclei segmentation and detection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562946/
https://www.ncbi.nlm.nih.gov/pubmed/31126166
http://dx.doi.org/10.3390/cells8050499
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