Cargando…
Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models
Blood circulation disorders, such as hyperlipidemia and arteriosclerosis, are not easily cured by dietary supplements, but they can be mitigated. Although Ecklonia cava extract (ECE), as dietary supplements, are associated with improving the conditions, there are not many studies verifying the same....
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562948/ https://www.ncbi.nlm.nih.gov/pubmed/31071969 http://dx.doi.org/10.3390/md17050272 |
_version_ | 1783426439892172800 |
---|---|
author | Son, Myeongjoo Oh, Seyeon Lee, Hye Sun Ryu, BoMi Jiang, Yunfei Jang, Ji Tae Jeon, You-Jin Byun, Kyunghee |
author_facet | Son, Myeongjoo Oh, Seyeon Lee, Hye Sun Ryu, BoMi Jiang, Yunfei Jang, Ji Tae Jeon, You-Jin Byun, Kyunghee |
author_sort | Son, Myeongjoo |
collection | PubMed |
description | Blood circulation disorders, such as hyperlipidemia and arteriosclerosis, are not easily cured by dietary supplements, but they can be mitigated. Although Ecklonia cava extract (ECE), as dietary supplements, are associated with improving the conditions, there are not many studies verifying the same. In this study, the beneficial effect of ECE and leaf of Ginkgo biloba extract (GBE), which is a well-known dietary supplement, were first confirmed in a diet induced-obese model. Afterwards, 4 phlorotannins were isolated from ECE, and their inhibitory effects on vascular cell dysfunction were validated. Pyrogallol-phloroglucinol-6,6-bieckol (PPB) was selected to be orally administered in two mice models: the diet induced obese model and diet induced hypertension model. After four weeks of administration, the blood pressure of all mice was measured, after which they were subsequently sacrificed. PPB was found to significantly improve blood circulation, including a reduction of adhesion molecule expression, endothelial cell (EC) death, excessive vascular smooth muscle cell (VSMC) proliferation and migration, blood pressure, and lipoprotein and cholesterol levels. Based on the excellent efficacy in diet-induced mouse models of obese and hypertension, our results demonstrate that PPB is a valuable active compound from among the phlorotannins that were isolated and it has the potential to be used in functional foods for improving the blood circulation. |
format | Online Article Text |
id | pubmed-6562948 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65629482019-06-17 Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models Son, Myeongjoo Oh, Seyeon Lee, Hye Sun Ryu, BoMi Jiang, Yunfei Jang, Ji Tae Jeon, You-Jin Byun, Kyunghee Mar Drugs Article Blood circulation disorders, such as hyperlipidemia and arteriosclerosis, are not easily cured by dietary supplements, but they can be mitigated. Although Ecklonia cava extract (ECE), as dietary supplements, are associated with improving the conditions, there are not many studies verifying the same. In this study, the beneficial effect of ECE and leaf of Ginkgo biloba extract (GBE), which is a well-known dietary supplement, were first confirmed in a diet induced-obese model. Afterwards, 4 phlorotannins were isolated from ECE, and their inhibitory effects on vascular cell dysfunction were validated. Pyrogallol-phloroglucinol-6,6-bieckol (PPB) was selected to be orally administered in two mice models: the diet induced obese model and diet induced hypertension model. After four weeks of administration, the blood pressure of all mice was measured, after which they were subsequently sacrificed. PPB was found to significantly improve blood circulation, including a reduction of adhesion molecule expression, endothelial cell (EC) death, excessive vascular smooth muscle cell (VSMC) proliferation and migration, blood pressure, and lipoprotein and cholesterol levels. Based on the excellent efficacy in diet-induced mouse models of obese and hypertension, our results demonstrate that PPB is a valuable active compound from among the phlorotannins that were isolated and it has the potential to be used in functional foods for improving the blood circulation. MDPI 2019-05-08 /pmc/articles/PMC6562948/ /pubmed/31071969 http://dx.doi.org/10.3390/md17050272 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Son, Myeongjoo Oh, Seyeon Lee, Hye Sun Ryu, BoMi Jiang, Yunfei Jang, Ji Tae Jeon, You-Jin Byun, Kyunghee Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models |
title | Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models |
title_full | Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models |
title_fullStr | Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models |
title_full_unstemmed | Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models |
title_short | Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models |
title_sort | pyrogallol-phloroglucinol-6,6’-bieckol from ecklonia cava improved blood circulation in diet-induced obese and diet-induced hypertension mouse models |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562948/ https://www.ncbi.nlm.nih.gov/pubmed/31071969 http://dx.doi.org/10.3390/md17050272 |
work_keys_str_mv | AT sonmyeongjoo pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels AT ohseyeon pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels AT leehyesun pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels AT ryubomi pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels AT jiangyunfei pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels AT jangjitae pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels AT jeonyoujin pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels AT byunkyunghee pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels |