Cargando…

Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models

Blood circulation disorders, such as hyperlipidemia and arteriosclerosis, are not easily cured by dietary supplements, but they can be mitigated. Although Ecklonia cava extract (ECE), as dietary supplements, are associated with improving the conditions, there are not many studies verifying the same....

Descripción completa

Detalles Bibliográficos
Autores principales: Son, Myeongjoo, Oh, Seyeon, Lee, Hye Sun, Ryu, BoMi, Jiang, Yunfei, Jang, Ji Tae, Jeon, You-Jin, Byun, Kyunghee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562948/
https://www.ncbi.nlm.nih.gov/pubmed/31071969
http://dx.doi.org/10.3390/md17050272
_version_ 1783426439892172800
author Son, Myeongjoo
Oh, Seyeon
Lee, Hye Sun
Ryu, BoMi
Jiang, Yunfei
Jang, Ji Tae
Jeon, You-Jin
Byun, Kyunghee
author_facet Son, Myeongjoo
Oh, Seyeon
Lee, Hye Sun
Ryu, BoMi
Jiang, Yunfei
Jang, Ji Tae
Jeon, You-Jin
Byun, Kyunghee
author_sort Son, Myeongjoo
collection PubMed
description Blood circulation disorders, such as hyperlipidemia and arteriosclerosis, are not easily cured by dietary supplements, but they can be mitigated. Although Ecklonia cava extract (ECE), as dietary supplements, are associated with improving the conditions, there are not many studies verifying the same. In this study, the beneficial effect of ECE and leaf of Ginkgo biloba extract (GBE), which is a well-known dietary supplement, were first confirmed in a diet induced-obese model. Afterwards, 4 phlorotannins were isolated from ECE, and their inhibitory effects on vascular cell dysfunction were validated. Pyrogallol-phloroglucinol-6,6-bieckol (PPB) was selected to be orally administered in two mice models: the diet induced obese model and diet induced hypertension model. After four weeks of administration, the blood pressure of all mice was measured, after which they were subsequently sacrificed. PPB was found to significantly improve blood circulation, including a reduction of adhesion molecule expression, endothelial cell (EC) death, excessive vascular smooth muscle cell (VSMC) proliferation and migration, blood pressure, and lipoprotein and cholesterol levels. Based on the excellent efficacy in diet-induced mouse models of obese and hypertension, our results demonstrate that PPB is a valuable active compound from among the phlorotannins that were isolated and it has the potential to be used in functional foods for improving the blood circulation.
format Online
Article
Text
id pubmed-6562948
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-65629482019-06-17 Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models Son, Myeongjoo Oh, Seyeon Lee, Hye Sun Ryu, BoMi Jiang, Yunfei Jang, Ji Tae Jeon, You-Jin Byun, Kyunghee Mar Drugs Article Blood circulation disorders, such as hyperlipidemia and arteriosclerosis, are not easily cured by dietary supplements, but they can be mitigated. Although Ecklonia cava extract (ECE), as dietary supplements, are associated with improving the conditions, there are not many studies verifying the same. In this study, the beneficial effect of ECE and leaf of Ginkgo biloba extract (GBE), which is a well-known dietary supplement, were first confirmed in a diet induced-obese model. Afterwards, 4 phlorotannins were isolated from ECE, and their inhibitory effects on vascular cell dysfunction were validated. Pyrogallol-phloroglucinol-6,6-bieckol (PPB) was selected to be orally administered in two mice models: the diet induced obese model and diet induced hypertension model. After four weeks of administration, the blood pressure of all mice was measured, after which they were subsequently sacrificed. PPB was found to significantly improve blood circulation, including a reduction of adhesion molecule expression, endothelial cell (EC) death, excessive vascular smooth muscle cell (VSMC) proliferation and migration, blood pressure, and lipoprotein and cholesterol levels. Based on the excellent efficacy in diet-induced mouse models of obese and hypertension, our results demonstrate that PPB is a valuable active compound from among the phlorotannins that were isolated and it has the potential to be used in functional foods for improving the blood circulation. MDPI 2019-05-08 /pmc/articles/PMC6562948/ /pubmed/31071969 http://dx.doi.org/10.3390/md17050272 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Son, Myeongjoo
Oh, Seyeon
Lee, Hye Sun
Ryu, BoMi
Jiang, Yunfei
Jang, Ji Tae
Jeon, You-Jin
Byun, Kyunghee
Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models
title Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models
title_full Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models
title_fullStr Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models
title_full_unstemmed Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models
title_short Pyrogallol-Phloroglucinol-6,6’-Bieckol from Ecklonia cava Improved Blood Circulation in Diet-Induced Obese and Diet-Induced Hypertension Mouse Models
title_sort pyrogallol-phloroglucinol-6,6’-bieckol from ecklonia cava improved blood circulation in diet-induced obese and diet-induced hypertension mouse models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562948/
https://www.ncbi.nlm.nih.gov/pubmed/31071969
http://dx.doi.org/10.3390/md17050272
work_keys_str_mv AT sonmyeongjoo pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels
AT ohseyeon pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels
AT leehyesun pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels
AT ryubomi pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels
AT jiangyunfei pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels
AT jangjitae pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels
AT jeonyoujin pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels
AT byunkyunghee pyrogallolphloroglucinol66bieckolfromeckloniacavaimprovedbloodcirculationindietinducedobeseanddietinducedhypertensionmousemodels