Cargando…

Nilotinib: A Tyrosine Kinase Inhibitor Mediates Resistance to Intracellular Mycobacterium Via Regulating Autophagy

Nilotinib, a tyrosine kinase inhibitor, has been studied extensively in various tumor models; however, no information exists about the pharmacological action of nilotinib in bacterial infections. Mycobacterium bovis (M. bovis) and Mycobacterium avium subspecies paratuberculosis (MAP) are the etiolog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hussain, Tariq, Zhao, Deming, Shah, Syed Zahid Ali, Sabir, Naveed, Wang, Jie, Liao, Yi, Song, Yinjuan, Dong, Haodi, Hussain Mangi, Mazhar, Ni, Jiamin, Yang, Lifeng, Zhou, Xiangmei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562972/ https://www.ncbi.nlm.nih.gov/pubmed/31130711 http://dx.doi.org/10.3390/cells8050506

Ejemplares similares

PP2Ac Modulates AMPK-Mediated Induction of Autophagy in Mycobacterium bovis-Infected Macrophages
por: Hussain, Tariq, et al.
Publicado: (2019)

Inhibition of type I interferon signaling abrogates early Mycobacterium bovis infection
por: Wang, Jie, et al.
Publicado: (2019)

Kallikrein 12 Regulates Innate Resistance of Murine Macrophages against Mycobacterium bovis Infection by Modulating Autophagy and Apoptosis
por: Sabir, Naveed, et al.
Publicado: (2019)

p62-Keap1-NRF2-ARE Pathway: A Contentious Player for Selective Targeting of Autophagy, Oxidative Stress and Mitochondrial Dysfunction in Prion Diseases
por: Shah, Syed Zahid Ali, et al.
Publicado: (2018)

Matrix metalloproteinases: Expression, regulation and role in the immunopathology of tuberculosis
por: Sabir, Naveed, et al.
Publicado: (2019)

Combinatory FK506 and Minocycline Treatment Alleviates Prion-Induced Neurodegenerative Events via Caspase-Mediated MAPK-NRF2 Pathway
por: Shah, Syed Zahid Ali, et al.
Publicado: (2019)

Endoplasmic Reticulum Stress Induces Macrophages to Produce IL-1β During Mycobacterium bovis Infection via a Positive Feedback Loop Between Mitochondrial Damage and Inflammasome Activation
por: Liao, Yi, et al.
Publicado: (2019)

MicroRNA 27a-3p Regulates Antimicrobial Responses of Murine Macrophages Infected by Mycobacterium avium subspecies paratuberculosis by Targeting Interleukin-10 and TGF-β-Activated Protein Kinase 1 Binding Protein 2
por: Hussain, Tariq, et al.
Publicado: (2018)

IFN-β: A Contentious Player in Host–Pathogen Interaction in Tuberculosis
por: Sabir, Naveed, et al.
Publicado: (2017)

Comparative Study of the Molecular Basis of Pathogenicity of M. bovis Strains in a Mouse Model
por: Cheng, Guangyu, et al.
Publicado: (2018)

Regulation of MicroRNAs-Mediated Autophagic Flux: A New Regulatory Avenue for Neurodegenerative Diseases With Focus on Prion Diseases
por: Shah, Syed Zahid Ali, et al.
Publicado: (2018)

Effects of Flaxseed and Multi-Carbohydrase Enzymes on the Cecal Microbiota and Liver Inflammation of Laying Hens
por: Mangi, Mazhar Hussain, et al.
Publicado: (2021)

miRNAs in Tuberculosis: New Avenues for Diagnosis and Host-Directed Therapy
por: Sabir, Naveed, et al.
Publicado: (2018)

The role of IL-10 in Mycobacterium avium subsp. paratuberculosis infection
por: Hussain, Tariq, et al.
Publicado: (2016)

Mycobacterium bovis induces mitophagy to suppress host xenophagy for its intracellular survival
por: Song, Yinjuan, et al.
Publicado: (2021)

CFP10–loaded PLGA nanoparticles as a booster vaccine confer protective immunity against Mycobacterium bovis
por: Liang, Zhengmin, et al.
Publicado: (2022)

MicroRNA-199a Inhibits Cellular Autophagy and Downregulates IFN-β Expression by Targeting TBK1 in Mycobacterium bovis Infected Cells
por: Wang, Jie, et al.
Publicado: (2018)

Virulent Mycobacterium bovis Beijing Strain Activates the NLRP7 Inflammasome in THP-1 Macrophages
por: Zhou, Yang, et al.
Publicado: (2016)

Differences in pathogenicity of three animal isolates of Mycobacterium species in a mouse model
por: Dong, Haodi, et al.
Publicado: (2017)

The Role of Unfolded Protein Response and Mitogen-Activated Protein Kinase Signaling in Neurodegenerative Diseases with Special Focus on Prion Diseases
por: Shah, Syed Zahid Ali, et al.
Publicado: (2017)

The Central Role of IFI204 in IFN-β Release and Autophagy Activation during Mycobacterium bovis Infection
por: Chunfa, Liu, et al.
Publicado: (2017)

Downregulation of the Repressor Element 1-Silencing Transcription Factor (REST) Is Associated with Akt-mTOR and Wnt-β-Catenin Signaling in Prion Diseases Models
por: Song, Zhiqi, et al.
Publicado: (2017)

A proof-of-concept study with the tyrosine kinase inhibitor nilotinib in spondyloarthritis
por: Paramarta, Jacqueline E., et al.
Publicado: (2016)

Aortic Stenosis and the Tyrosine Kinase Inhibitor Nilotinib in Chronic Myeloid Leukemia
por: Carracedo, Miguel, et al.
Publicado: (2020)

The NLRP3-Caspase 1 Inflammasome Negatively Regulates Autophagy via TLR4-TRIF in Prion Peptide-Infected Microglia
por: Lai, Mengyu, et al.
Publicado: (2018)

Overexpression of matrix metalloproteinase‐9 in breast cancer cell lines remarkably increases the cell malignancy largely via activation of transforming growth factor beta/SMAD signalling
por: Dong, Haodi, et al.
Publicado: (2019)

Extensive intracranial arterial stenoses in conjunction with the use of tyrosine kinase inhibitor Nilotinib
por: Alshiekh‐Nasany, Ruham, et al.
Publicado: (2016)

Lichen planopilaris-like eruption during treatment with tyrosine kinase inhibitor nilotinib
por: Leitão, Juliana Ribeiro, et al.
Publicado: (2016)

Sodium Butyrate Abrogates the Growth and Pathogenesis of Mycobacterium bovis via Regulation of Cathelicidin (LL37) Expression and NF-κB Signaling
por: Zhang, Kai, et al.
Publicado: (2020)

Alteration of Autophagy and Glial Activity in Nilotinib-Treated Huntington’s Disease Patients
por: Anderson, Karen E., et al.
Publicado: (2022)

Defensins: The Case for Their Use against Mycobacterial Infections
por: Dong, Haodi, et al.
Publicado: (2016)

The isolation and molecular characterization of Mycobacterium avium subsp. paratuberculosis in Shandong province, China
por: Yue, Ruichao, et al.
Publicado: (2016)

AIM2 inhibits autophagy and IFN-β production during M. bovis infection
por: Liu, Chunfa, et al.
Publicado: (2016)

Gene expression signatures associated with the in vitro resistance to two tyrosine kinase inhibitors, nilotinib and imatinib
por: Kim, T-M, et al.
Publicado: (2011)

Preclinical pharmacokinetic evaluation to facilitate repurposing of tyrosine kinase inhibitors nilotinib and imatinib as antiviral agents
por: Ananthula, Hari Krishna, et al.
Publicado: (2018)

Bazedoxifene Suppresses Intracellular Mycobacterium tuberculosis Growth by Enhancing Autophagy
por: Ouyang, Qi, et al.
Publicado: (2020)

Association analysis of single nucleotide polymorphisms in autophagy related 7 (ATG7) gene in patients with coronary artery disease
por: Sarosh, Moomal, et al.
Publicado: (2022)

Antimicrobial Activities and Biopreservation Potential of Lactic Acid Bacteria (LAB) from Raw Buffalo (Bubalus bubalis) Milk
por: Kalhoro, Muhammad Saleem, et al.
Publicado: (2023)

Nilotinib-Associated Destructive Thyroiditis
por: Bakerywala, Suhalia, et al.
Publicado: (2015)

Nilotinib-Induced Keratosis Pilaris
por: Leong, Wai Mun Sean, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_pjikcaksh56te2cjvf4k0niaiv