Mitochondrial Function, Mobility and Lifespan Are Improved in Drosophila melanogaster by Extracts of 9-cis-β-Carotene from Dunaliella salina

Carotenoids are implicated in alleviating ageing and age-related diseases in humans. While data from different carotenoids are mixed in their outcomes, those for 9-cis-β-carotene indicate general positive effects, although basic data on its biological impact are limited. Here, we show that supplemen...

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Autores principales: Weinrich, Tobias, Xu, Yanan, Wosu, Chiziezi, Harvey, Patricia J., Jeffery, Glen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563070/
https://www.ncbi.nlm.nih.gov/pubmed/31083322
http://dx.doi.org/10.3390/md17050279
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author Weinrich, Tobias
Xu, Yanan
Wosu, Chiziezi
Harvey, Patricia J.
Jeffery, Glen
author_facet Weinrich, Tobias
Xu, Yanan
Wosu, Chiziezi
Harvey, Patricia J.
Jeffery, Glen
author_sort Weinrich, Tobias
collection PubMed
description Carotenoids are implicated in alleviating ageing and age-related diseases in humans. While data from different carotenoids are mixed in their outcomes, those for 9-cis-β-carotene indicate general positive effects, although basic data on its biological impact are limited. Here, we show that supplementation with 9-cis-β-carotene in ageing Drosophila melanogaster improved mitochondrial function in terms of ATP production and whole-body respiration and extended mean lifespan. It also resulted in improved mobility. These data provide a potential biological rational for the beneficial effects of dietary supplementation with 9-cis-β-carotene. These effects may be based on the maintenance of a sound mitochondrial function.
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spelling pubmed-65630702019-06-17 Mitochondrial Function, Mobility and Lifespan Are Improved in Drosophila melanogaster by Extracts of 9-cis-β-Carotene from Dunaliella salina Weinrich, Tobias Xu, Yanan Wosu, Chiziezi Harvey, Patricia J. Jeffery, Glen Mar Drugs Article Carotenoids are implicated in alleviating ageing and age-related diseases in humans. While data from different carotenoids are mixed in their outcomes, those for 9-cis-β-carotene indicate general positive effects, although basic data on its biological impact are limited. Here, we show that supplementation with 9-cis-β-carotene in ageing Drosophila melanogaster improved mitochondrial function in terms of ATP production and whole-body respiration and extended mean lifespan. It also resulted in improved mobility. These data provide a potential biological rational for the beneficial effects of dietary supplementation with 9-cis-β-carotene. These effects may be based on the maintenance of a sound mitochondrial function. MDPI 2019-05-10 /pmc/articles/PMC6563070/ /pubmed/31083322 http://dx.doi.org/10.3390/md17050279 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Weinrich, Tobias
Xu, Yanan
Wosu, Chiziezi
Harvey, Patricia J.
Jeffery, Glen
Mitochondrial Function, Mobility and Lifespan Are Improved in Drosophila melanogaster by Extracts of 9-cis-β-Carotene from Dunaliella salina
title Mitochondrial Function, Mobility and Lifespan Are Improved in Drosophila melanogaster by Extracts of 9-cis-β-Carotene from Dunaliella salina
title_full Mitochondrial Function, Mobility and Lifespan Are Improved in Drosophila melanogaster by Extracts of 9-cis-β-Carotene from Dunaliella salina
title_fullStr Mitochondrial Function, Mobility and Lifespan Are Improved in Drosophila melanogaster by Extracts of 9-cis-β-Carotene from Dunaliella salina
title_full_unstemmed Mitochondrial Function, Mobility and Lifespan Are Improved in Drosophila melanogaster by Extracts of 9-cis-β-Carotene from Dunaliella salina
title_short Mitochondrial Function, Mobility and Lifespan Are Improved in Drosophila melanogaster by Extracts of 9-cis-β-Carotene from Dunaliella salina
title_sort mitochondrial function, mobility and lifespan are improved in drosophila melanogaster by extracts of 9-cis-β-carotene from dunaliella salina
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563070/
https://www.ncbi.nlm.nih.gov/pubmed/31083322
http://dx.doi.org/10.3390/md17050279
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