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High prevalence and poor linkage to care of transfusion‐transmitted infections among blood donors in Dar‐es‐Salaam, Tanzania

Blood transfusion is one of the most commonly relied upon therapies in sub‐Saharan Africa. Existing safeguards recommended include systematic screening for transfusion‐transmitted infections and restricted voluntary nonremunerated blood donor selection. We report the transfusion‐transmitted infectio...

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Autores principales: Mohamed, Zameer, Kim, Jin U., Magesa, Alex, Kasubi, Mabula, Feldman, Sarah F., Chevaliez, Stephane, Mwakale, Promise, Taylor‐Robinson, Simon D., Thursz, Mark R., Shimakawa, Yusuke, Rwegasha, John, Lemoine, Maud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563112/
https://www.ncbi.nlm.nih.gov/pubmed/30712273
http://dx.doi.org/10.1111/jvh.13073
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author Mohamed, Zameer
Kim, Jin U.
Magesa, Alex
Kasubi, Mabula
Feldman, Sarah F.
Chevaliez, Stephane
Mwakale, Promise
Taylor‐Robinson, Simon D.
Thursz, Mark R.
Shimakawa, Yusuke
Rwegasha, John
Lemoine, Maud
author_facet Mohamed, Zameer
Kim, Jin U.
Magesa, Alex
Kasubi, Mabula
Feldman, Sarah F.
Chevaliez, Stephane
Mwakale, Promise
Taylor‐Robinson, Simon D.
Thursz, Mark R.
Shimakawa, Yusuke
Rwegasha, John
Lemoine, Maud
author_sort Mohamed, Zameer
collection PubMed
description Blood transfusion is one of the most commonly relied upon therapies in sub‐Saharan Africa. Existing safeguards recommended include systematic screening for transfusion‐transmitted infections and restricted voluntary nonremunerated blood donor selection. We report the transfusion‐transmitted infection screening and notification practice at a large urban blood transfusion centre in Dar‐es‐Salaam, Tanzania. Between October 2016 and March 2017 anonymized records of all donors registered at the blood transfusion unit were accessed to retrospectively note demographic information, donor status, first‐time status, transfusion‐transmitted infection result and notification. 6402 consecutive donors were screened for transfusion‐transmitted infections; the majority were family/replacement blood donors (88.0%) and male (83.8%). Overall transfusion‐transmitted infections prevalence was 8.4% (95% CI 7.8‐9.1), with hepatitis B being the most prevalent infection (4.1% (95% CI 3.6‐4.6)). Transfusion‐transmitted infections were more common in family/replacement blood donors (9.0% (95% CI 8.3‐9.8)) as compared to voluntary nonremunerated blood donor (4.1% (95% CI 2.8‐5.7)). A minority of infected‐donors were notified of a positive result (8.5% (95% CI 6.3‐11.2)). Although transfusion‐transmitted infections are more prevalent among family/replacement blood donors, overall risk of transfusion‐transmitted infections across all groups is considerable. In addition, existing efforts to notify donors of a positive transfusion‐transmitted infection are poor. Future policies must focus on improving linkage to care for newly diagnosed patients with transfusion‐transmitted infections.
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spelling pubmed-65631122019-06-17 High prevalence and poor linkage to care of transfusion‐transmitted infections among blood donors in Dar‐es‐Salaam, Tanzania Mohamed, Zameer Kim, Jin U. Magesa, Alex Kasubi, Mabula Feldman, Sarah F. Chevaliez, Stephane Mwakale, Promise Taylor‐Robinson, Simon D. Thursz, Mark R. Shimakawa, Yusuke Rwegasha, John Lemoine, Maud J Viral Hepat Original Articles Blood transfusion is one of the most commonly relied upon therapies in sub‐Saharan Africa. Existing safeguards recommended include systematic screening for transfusion‐transmitted infections and restricted voluntary nonremunerated blood donor selection. We report the transfusion‐transmitted infection screening and notification practice at a large urban blood transfusion centre in Dar‐es‐Salaam, Tanzania. Between October 2016 and March 2017 anonymized records of all donors registered at the blood transfusion unit were accessed to retrospectively note demographic information, donor status, first‐time status, transfusion‐transmitted infection result and notification. 6402 consecutive donors were screened for transfusion‐transmitted infections; the majority were family/replacement blood donors (88.0%) and male (83.8%). Overall transfusion‐transmitted infections prevalence was 8.4% (95% CI 7.8‐9.1), with hepatitis B being the most prevalent infection (4.1% (95% CI 3.6‐4.6)). Transfusion‐transmitted infections were more common in family/replacement blood donors (9.0% (95% CI 8.3‐9.8)) as compared to voluntary nonremunerated blood donor (4.1% (95% CI 2.8‐5.7)). A minority of infected‐donors were notified of a positive result (8.5% (95% CI 6.3‐11.2)). Although transfusion‐transmitted infections are more prevalent among family/replacement blood donors, overall risk of transfusion‐transmitted infections across all groups is considerable. In addition, existing efforts to notify donors of a positive transfusion‐transmitted infection are poor. Future policies must focus on improving linkage to care for newly diagnosed patients with transfusion‐transmitted infections. John Wiley and Sons Inc. 2019-02-27 2019-06 /pmc/articles/PMC6563112/ /pubmed/30712273 http://dx.doi.org/10.1111/jvh.13073 Text en © 2019 The Authors. Journal of Viral Hepatitis Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Mohamed, Zameer
Kim, Jin U.
Magesa, Alex
Kasubi, Mabula
Feldman, Sarah F.
Chevaliez, Stephane
Mwakale, Promise
Taylor‐Robinson, Simon D.
Thursz, Mark R.
Shimakawa, Yusuke
Rwegasha, John
Lemoine, Maud
High prevalence and poor linkage to care of transfusion‐transmitted infections among blood donors in Dar‐es‐Salaam, Tanzania
title High prevalence and poor linkage to care of transfusion‐transmitted infections among blood donors in Dar‐es‐Salaam, Tanzania
title_full High prevalence and poor linkage to care of transfusion‐transmitted infections among blood donors in Dar‐es‐Salaam, Tanzania
title_fullStr High prevalence and poor linkage to care of transfusion‐transmitted infections among blood donors in Dar‐es‐Salaam, Tanzania
title_full_unstemmed High prevalence and poor linkage to care of transfusion‐transmitted infections among blood donors in Dar‐es‐Salaam, Tanzania
title_short High prevalence and poor linkage to care of transfusion‐transmitted infections among blood donors in Dar‐es‐Salaam, Tanzania
title_sort high prevalence and poor linkage to care of transfusion‐transmitted infections among blood donors in dar‐es‐salaam, tanzania
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563112/
https://www.ncbi.nlm.nih.gov/pubmed/30712273
http://dx.doi.org/10.1111/jvh.13073
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