Cardiometabolic Polygenic Risk Scores and Osteoarthritis Outcomes: A Mendelian Randomization Study Using Data From the Malmö Diet and Cancer Study and the UK Biobank

OBJECTIVE: To investigate the causal role of cardiometabolic risk factors in osteoarthritis (OA) using associated genetic variants. METHODS: We studied 27,691 adults from the Malmö Diet and Cancer Study (MDCS) and replicated novel findings among 376,435 adults from the UK Biobank. Trait‐specific pol...

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Detalles Bibliográficos
Autores principales: Hindy, George, Åkesson, Kristina E., Melander, Olle, Aragam, Krishna G., Haas, Mary E., Nilsson, Peter M., Kadam, Umesh T., Orho‐Melander, Marju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Osteoarthritis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563114/
https://www.ncbi.nlm.nih.gov/pubmed/30615301
http://dx.doi.org/10.1002/art.40812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563114/
https://www.ncbi.nlm.nih.gov/pubmed/30615301
http://dx.doi.org/10.1002/art.40812

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