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Azaphilones from the Marine Sponge-Derived Fungus Penicillium sclerotiorum OUCMDZ-3839

Four new azaphilones, sclerotiorins A–D (1–4), as well as the dimeric sclerotiorin E (5) of which we first determined its absolute configuration, and 12 known analogues (5–16) were isolated from the fermentation broth of Penicillium sclerotiorum OUCMDZ-3839 associated with a marine sponge Paratetill...

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Detalles Bibliográficos
Autores principales: Jia, Qian, Du, Yuqi, Wang, Chen, Wang, Yi, Zhu, Tonghan, Zhu, Weiming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563140/
https://www.ncbi.nlm.nih.gov/pubmed/31052279
http://dx.doi.org/10.3390/md17050260
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author Jia, Qian
Du, Yuqi
Wang, Chen
Wang, Yi
Zhu, Tonghan
Zhu, Weiming
author_facet Jia, Qian
Du, Yuqi
Wang, Chen
Wang, Yi
Zhu, Tonghan
Zhu, Weiming
author_sort Jia, Qian
collection PubMed
description Four new azaphilones, sclerotiorins A–D (1–4), as well as the dimeric sclerotiorin E (5) of which we first determined its absolute configuration, and 12 known analogues (5–16) were isolated from the fermentation broth of Penicillium sclerotiorum OUCMDZ-3839 associated with a marine sponge Paratetilla sp.. The new structures, including absolute configurations, were elucidated by spectroscopic analyses, optical rotation, ECD spectra, X-ray single-crystal diffraction, and chemical transformations. Compounds 11 and 14 displayed significant inhibitory activity against α-glycosidase, with IC(50) values of 17.3 and 166.1 μM, respectively. In addition, compounds 5, 7, 10, 12–14, and 16 showed moderate bioactivity against H1N1 virus.
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spelling pubmed-65631402019-06-17 Azaphilones from the Marine Sponge-Derived Fungus Penicillium sclerotiorum OUCMDZ-3839 Jia, Qian Du, Yuqi Wang, Chen Wang, Yi Zhu, Tonghan Zhu, Weiming Mar Drugs Communication Four new azaphilones, sclerotiorins A–D (1–4), as well as the dimeric sclerotiorin E (5) of which we first determined its absolute configuration, and 12 known analogues (5–16) were isolated from the fermentation broth of Penicillium sclerotiorum OUCMDZ-3839 associated with a marine sponge Paratetilla sp.. The new structures, including absolute configurations, were elucidated by spectroscopic analyses, optical rotation, ECD spectra, X-ray single-crystal diffraction, and chemical transformations. Compounds 11 and 14 displayed significant inhibitory activity against α-glycosidase, with IC(50) values of 17.3 and 166.1 μM, respectively. In addition, compounds 5, 7, 10, 12–14, and 16 showed moderate bioactivity against H1N1 virus. MDPI 2019-04-30 /pmc/articles/PMC6563140/ /pubmed/31052279 http://dx.doi.org/10.3390/md17050260 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Jia, Qian
Du, Yuqi
Wang, Chen
Wang, Yi
Zhu, Tonghan
Zhu, Weiming
Azaphilones from the Marine Sponge-Derived Fungus Penicillium sclerotiorum OUCMDZ-3839
title Azaphilones from the Marine Sponge-Derived Fungus Penicillium sclerotiorum OUCMDZ-3839
title_full Azaphilones from the Marine Sponge-Derived Fungus Penicillium sclerotiorum OUCMDZ-3839
title_fullStr Azaphilones from the Marine Sponge-Derived Fungus Penicillium sclerotiorum OUCMDZ-3839
title_full_unstemmed Azaphilones from the Marine Sponge-Derived Fungus Penicillium sclerotiorum OUCMDZ-3839
title_short Azaphilones from the Marine Sponge-Derived Fungus Penicillium sclerotiorum OUCMDZ-3839
title_sort azaphilones from the marine sponge-derived fungus penicillium sclerotiorum oucmdz-3839
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563140/
https://www.ncbi.nlm.nih.gov/pubmed/31052279
http://dx.doi.org/10.3390/md17050260
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