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Roles of Hepatitis B Virus Mutations in the Viral Reactivation after Immunosuppression Therapies

Reactivation of hepatitis B virus (HBV) is a major problem in patients receiving chemotherapy for malignant diseases or immunosuppression therapies. It has been thought that a reduction in the immune responses might result in the reactivation of HBV replication from covalently closed circular DNA (c...

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Autores principales: Inoue, Jun, Nakamura, Takuya, Masamune, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563158/
https://www.ncbi.nlm.nih.gov/pubmed/31109119
http://dx.doi.org/10.3390/v11050457
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author Inoue, Jun
Nakamura, Takuya
Masamune, Atsushi
author_facet Inoue, Jun
Nakamura, Takuya
Masamune, Atsushi
author_sort Inoue, Jun
collection PubMed
description Reactivation of hepatitis B virus (HBV) is a major problem in patients receiving chemotherapy for malignant diseases or immunosuppression therapies. It has been thought that a reduction in the immune responses might result in the reactivation of HBV replication from covalently closed circular DNA (cccDNA) residing in hepatocytes. However, not only the host’s immune status, but also viral mutations have been reported to be associated with reactivation. Especially, several case reports about amino acid mutations in hepatitis B surface antigen (HBsAg) that escape from immune reactions have been reported, and recent reports showed that the frequencies of such mutations are higher than previously expected. In this review, we summarize the characteristics of viral mutations, including immune escape mutations in HBV-reactivated patients, and discuss their significance.
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spelling pubmed-65631582019-06-17 Roles of Hepatitis B Virus Mutations in the Viral Reactivation after Immunosuppression Therapies Inoue, Jun Nakamura, Takuya Masamune, Atsushi Viruses Review Reactivation of hepatitis B virus (HBV) is a major problem in patients receiving chemotherapy for malignant diseases or immunosuppression therapies. It has been thought that a reduction in the immune responses might result in the reactivation of HBV replication from covalently closed circular DNA (cccDNA) residing in hepatocytes. However, not only the host’s immune status, but also viral mutations have been reported to be associated with reactivation. Especially, several case reports about amino acid mutations in hepatitis B surface antigen (HBsAg) that escape from immune reactions have been reported, and recent reports showed that the frequencies of such mutations are higher than previously expected. In this review, we summarize the characteristics of viral mutations, including immune escape mutations in HBV-reactivated patients, and discuss their significance. MDPI 2019-05-19 /pmc/articles/PMC6563158/ /pubmed/31109119 http://dx.doi.org/10.3390/v11050457 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Inoue, Jun
Nakamura, Takuya
Masamune, Atsushi
Roles of Hepatitis B Virus Mutations in the Viral Reactivation after Immunosuppression Therapies
title Roles of Hepatitis B Virus Mutations in the Viral Reactivation after Immunosuppression Therapies
title_full Roles of Hepatitis B Virus Mutations in the Viral Reactivation after Immunosuppression Therapies
title_fullStr Roles of Hepatitis B Virus Mutations in the Viral Reactivation after Immunosuppression Therapies
title_full_unstemmed Roles of Hepatitis B Virus Mutations in the Viral Reactivation after Immunosuppression Therapies
title_short Roles of Hepatitis B Virus Mutations in the Viral Reactivation after Immunosuppression Therapies
title_sort roles of hepatitis b virus mutations in the viral reactivation after immunosuppression therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563158/
https://www.ncbi.nlm.nih.gov/pubmed/31109119
http://dx.doi.org/10.3390/v11050457
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