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Multiple genetic analyses to investigate the polymorphisms of Chinese Mongolian population with an efficient short tandem repeat panel

AIM: To determine allele frequencies and forensic statistics of 22 autosomal short tandem repeat loci in Chinese Mongolian population. METHODS: Blood specimens were collected from 134 unrelated healthy Mongolian individuals, and 22 short tandem repeat loci were co-amplified and genotyped. Allele fre...

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Autores principales: Fang, Yating, Xie, Tong, Lan, Qiong, Jin, Xiaoye, Guo, Yuxin, Zhou, Yongsong, Yan, Jiangwei, Zhu, Bofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Medical Schools 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563180/
https://www.ncbi.nlm.nih.gov/pubmed/31187946
http://dx.doi.org/10.3325/cmj.2019.60.191
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author Fang, Yating
Xie, Tong
Lan, Qiong
Jin, Xiaoye
Guo, Yuxin
Zhou, Yongsong
Yan, Jiangwei
Zhu, Bofeng
author_facet Fang, Yating
Xie, Tong
Lan, Qiong
Jin, Xiaoye
Guo, Yuxin
Zhou, Yongsong
Yan, Jiangwei
Zhu, Bofeng
author_sort Fang, Yating
collection PubMed
description AIM: To determine allele frequencies and forensic statistics of 22 autosomal short tandem repeat loci in Chinese Mongolian population. METHODS: Blood specimens were collected from 134 unrelated healthy Mongolian individuals, and 22 short tandem repeat loci were co-amplified and genotyped. Allele frequencies and forensic parameters were calculated, and population genetic differences were analyzed among Mongolian population and other eight Chinese populations: Northern Han, Guangdong Han, Chengdu Han, Xinjiang Hui, Xinjiang Uygur, Hainan Li, Qinghai Tibetan, and Hainan Han. RESULTS: All the loci were in the Hardy-Weinberg equilibrium, and after Bonferroni correction there was no linkage disequilibrium between them. The allele frequencies of these 22 loci were between 0.0037 and 0.3657. This panel had high discriminating power and genetic polymorphism in the Mongolian population, with combined power of discrimination of 0.999999999999999999999999998399 and combined probability of exclusion of 0.9999999999566925. Structure analysis showed no evidence that these nine Chinese populations had different component distribution. However, genetic distance analysis showed significant differences among them (P < 0.05). CONCLUSION: The combined application of these 22 loci could be useful for forensic purposes in the Mongolian population. Mongolian population had smaller genetic distances from the populations in northern China (Northern Han, Xinjiang Uygur, and Xinjiang Hui) than from the populations in Hainan province (Hainan Han and Hainan Li populations).
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spelling pubmed-65631802019-06-20 Multiple genetic analyses to investigate the polymorphisms of Chinese Mongolian population with an efficient short tandem repeat panel Fang, Yating Xie, Tong Lan, Qiong Jin, Xiaoye Guo, Yuxin Zhou, Yongsong Yan, Jiangwei Zhu, Bofeng Croat Med J 11th ISABS CONFERENCE AIM: To determine allele frequencies and forensic statistics of 22 autosomal short tandem repeat loci in Chinese Mongolian population. METHODS: Blood specimens were collected from 134 unrelated healthy Mongolian individuals, and 22 short tandem repeat loci were co-amplified and genotyped. Allele frequencies and forensic parameters were calculated, and population genetic differences were analyzed among Mongolian population and other eight Chinese populations: Northern Han, Guangdong Han, Chengdu Han, Xinjiang Hui, Xinjiang Uygur, Hainan Li, Qinghai Tibetan, and Hainan Han. RESULTS: All the loci were in the Hardy-Weinberg equilibrium, and after Bonferroni correction there was no linkage disequilibrium between them. The allele frequencies of these 22 loci were between 0.0037 and 0.3657. This panel had high discriminating power and genetic polymorphism in the Mongolian population, with combined power of discrimination of 0.999999999999999999999999998399 and combined probability of exclusion of 0.9999999999566925. Structure analysis showed no evidence that these nine Chinese populations had different component distribution. However, genetic distance analysis showed significant differences among them (P < 0.05). CONCLUSION: The combined application of these 22 loci could be useful for forensic purposes in the Mongolian population. Mongolian population had smaller genetic distances from the populations in northern China (Northern Han, Xinjiang Uygur, and Xinjiang Hui) than from the populations in Hainan province (Hainan Han and Hainan Li populations). Croatian Medical Schools 2019-06 /pmc/articles/PMC6563180/ /pubmed/31187946 http://dx.doi.org/10.3325/cmj.2019.60.191 Text en Copyright © 2019 by the Croatian Medical Journal. All rights reserved. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 11th ISABS CONFERENCE
Fang, Yating
Xie, Tong
Lan, Qiong
Jin, Xiaoye
Guo, Yuxin
Zhou, Yongsong
Yan, Jiangwei
Zhu, Bofeng
Multiple genetic analyses to investigate the polymorphisms of Chinese Mongolian population with an efficient short tandem repeat panel
title Multiple genetic analyses to investigate the polymorphisms of Chinese Mongolian population with an efficient short tandem repeat panel
title_full Multiple genetic analyses to investigate the polymorphisms of Chinese Mongolian population with an efficient short tandem repeat panel
title_fullStr Multiple genetic analyses to investigate the polymorphisms of Chinese Mongolian population with an efficient short tandem repeat panel
title_full_unstemmed Multiple genetic analyses to investigate the polymorphisms of Chinese Mongolian population with an efficient short tandem repeat panel
title_short Multiple genetic analyses to investigate the polymorphisms of Chinese Mongolian population with an efficient short tandem repeat panel
title_sort multiple genetic analyses to investigate the polymorphisms of chinese mongolian population with an efficient short tandem repeat panel
topic 11th ISABS CONFERENCE
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563180/
https://www.ncbi.nlm.nih.gov/pubmed/31187946
http://dx.doi.org/10.3325/cmj.2019.60.191
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