Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry

The hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic activities on interaction with sialic acid (SA), which is the receptor for virus attachment. HA binds SA through its receptor-binding sites, while NA is a receptor-destroying enzyme by removing SAs. The function...

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Autores principales: Du, Ruikun, Cui, Qinghua, Rong, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563287/
https://www.ncbi.nlm.nih.gov/pubmed/31137516
http://dx.doi.org/10.3390/v11050458
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author Du, Ruikun
Cui, Qinghua
Rong, Lijun
author_facet Du, Ruikun
Cui, Qinghua
Rong, Lijun
author_sort Du, Ruikun
collection PubMed
description The hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic activities on interaction with sialic acid (SA), which is the receptor for virus attachment. HA binds SA through its receptor-binding sites, while NA is a receptor-destroying enzyme by removing SAs. The function of HA during virus entry has been extensively investigated, however, examination of NA has long been focused to its role in the exit of progeny virus from infected cells, and the role of NA in the entry process is still under-appreciated. This review summarizes the current understanding of the roles of HA and NA in relation to each other during virus entry.
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spelling pubmed-65632872019-06-17 Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry Du, Ruikun Cui, Qinghua Rong, Lijun Viruses Review The hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic activities on interaction with sialic acid (SA), which is the receptor for virus attachment. HA binds SA through its receptor-binding sites, while NA is a receptor-destroying enzyme by removing SAs. The function of HA during virus entry has been extensively investigated, however, examination of NA has long been focused to its role in the exit of progeny virus from infected cells, and the role of NA in the entry process is still under-appreciated. This review summarizes the current understanding of the roles of HA and NA in relation to each other during virus entry. MDPI 2019-05-20 /pmc/articles/PMC6563287/ /pubmed/31137516 http://dx.doi.org/10.3390/v11050458 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Du, Ruikun
Cui, Qinghua
Rong, Lijun
Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry
title Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry
title_full Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry
title_fullStr Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry
title_full_unstemmed Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry
title_short Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry
title_sort competitive cooperation of hemagglutinin and neuraminidase during influenza a virus entry
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563287/
https://www.ncbi.nlm.nih.gov/pubmed/31137516
http://dx.doi.org/10.3390/v11050458
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AT cuiqinghua competitivecooperationofhemagglutininandneuraminidaseduringinfluenzaavirusentry
AT ronglijun competitivecooperationofhemagglutininandneuraminidaseduringinfluenzaavirusentry

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