Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer

Specific metabolic underpinnings of androgen receptor (AR)-driven growth in prostate adenocarcinoma (PCa) are largely undefined, hindering the development of strategies to leverage the metabolic dependencies of this disease when hormonal manipulations fail. Here we show that the mitochondrial pyruva...

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Detalles Bibliográficos
Autores principales: Bader, David A., Hartig, Sean M., Putluri, Vasanta, Foley, Christopher, Hamilton, Mark P., Smith, Eric A., Saha, Pradip K., Panigrahi, Anil, Walker, Christopher, Zong, Lin, Martini-Stoica, Heidi, Chen, Rui, Rajapakshe, Kimal, Coarfa, Cristian, Sreekumar, Arun, Mitsiades, Nicholas, Bankson, James A., Ittmann, Michael M., O’Malley, Bert W., Putluri, Nagireddy, McGuire, Sean E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563330/
https://www.ncbi.nlm.nih.gov/pubmed/31198906
http://dx.doi.org/10.1038/s42255-018-0002-y

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