Chemoenzymatic Total Synthesis of Deoxy‐, epi‐, and Podophyllotoxin and a Biocatalytic Kinetic Resolution of Dibenzylbutyrolactones

Podophyllotoxin is probably the most prominent representative of lignan natural products. Deoxy‐, epi‐, and podophyllotoxin, which are all precursors to frequently used chemotherapeutic agents, were prepared by a stereodivergent biotransformation and a biocatalytic kinetic resolution of the correspo...

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Detalles Bibliográficos
Autores principales: Lazzarotto, Mattia, Hammerer, Lucas, Hetmann, Michael, Borg, Annika, Schmermund, Luca, Steiner, Lorenz, Hartmann, Peter, Belaj, Ferdinand, Kroutil, Wolfgang, Gruber, Karl, Fuchs, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563474/
https://www.ncbi.nlm.nih.gov/pubmed/30920120
http://dx.doi.org/10.1002/anie.201900926

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