An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and non-malignant hematological diseases. However, graft-vs.-host disease (GVHD), one of the main complications after allo-HSCT, remains the major reason for morbidity...

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Detalles Bibliográficos
Autores principales: Shao, Liang, Pan, Shan, Zhang, Qiu-ping, Jamal, Muhammad, Chen, Lu-hua, Yin, Qian, Wu, Ying-jie, Xiong, Jie, Xiao, Rui-jing, Kwong, Yok-lam, Zhou, Fu-ling, Lie, Albert K. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563595/
https://www.ncbi.nlm.nih.gov/pubmed/31244831
http://dx.doi.org/10.3389/fimmu.2019.01233
Descripción
Sumario:Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and non-malignant hematological diseases. However, graft-vs.-host disease (GVHD), one of the main complications after allo-HSCT, remains the major reason for morbidity and non-relapse mortality. Emerging evidence has demonstrated that innate lymphoid cells (ILCs) play a non-redundant role in the pathophysiology of GVHD. In this review, we will summarize previously published data regarding the role of ILCs in the pathogenesis of GVHD.

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