An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease

Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and non-malignant hematological diseases. However, graft-vs.-host disease (GVHD), one of the main complications after allo-HSCT, remains the major reason for morbidity...

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Autores principales: Shao, Liang, Pan, Shan, Zhang, Qiu-ping, Jamal, Muhammad, Chen, Lu-hua, Yin, Qian, Wu, Ying-jie, Xiong, Jie, Xiao, Rui-jing, Kwong, Yok-lam, Zhou, Fu-ling, Lie, Albert K. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563595/
https://www.ncbi.nlm.nih.gov/pubmed/31244831
http://dx.doi.org/10.3389/fimmu.2019.01233
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author Shao, Liang
Pan, Shan
Zhang, Qiu-ping
Jamal, Muhammad
Chen, Lu-hua
Yin, Qian
Wu, Ying-jie
Xiong, Jie
Xiao, Rui-jing
Kwong, Yok-lam
Zhou, Fu-ling
Lie, Albert K. W.
author_facet Shao, Liang
Pan, Shan
Zhang, Qiu-ping
Jamal, Muhammad
Chen, Lu-hua
Yin, Qian
Wu, Ying-jie
Xiong, Jie
Xiao, Rui-jing
Kwong, Yok-lam
Zhou, Fu-ling
Lie, Albert K. W.
author_sort Shao, Liang
collection PubMed
description Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and non-malignant hematological diseases. However, graft-vs.-host disease (GVHD), one of the main complications after allo-HSCT, remains the major reason for morbidity and non-relapse mortality. Emerging evidence has demonstrated that innate lymphoid cells (ILCs) play a non-redundant role in the pathophysiology of GVHD. In this review, we will summarize previously published data regarding the role of ILCs in the pathogenesis of GVHD.
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spelling pubmed-65635952019-06-26 An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease Shao, Liang Pan, Shan Zhang, Qiu-ping Jamal, Muhammad Chen, Lu-hua Yin, Qian Wu, Ying-jie Xiong, Jie Xiao, Rui-jing Kwong, Yok-lam Zhou, Fu-ling Lie, Albert K. W. Front Immunol Immunology Allogeneic hematopoietic stem cell transplantation (Allo-HSCT) is the only curative treatment for multiple hematologic malignancies and non-malignant hematological diseases. However, graft-vs.-host disease (GVHD), one of the main complications after allo-HSCT, remains the major reason for morbidity and non-relapse mortality. Emerging evidence has demonstrated that innate lymphoid cells (ILCs) play a non-redundant role in the pathophysiology of GVHD. In this review, we will summarize previously published data regarding the role of ILCs in the pathogenesis of GVHD. Frontiers Media S.A. 2019-06-06 /pmc/articles/PMC6563595/ /pubmed/31244831 http://dx.doi.org/10.3389/fimmu.2019.01233 Text en Copyright © 2019 Shao, Pan, Zhang, Jamal, Chen, Yin, Wu, Xiong, Xiao, Kwong, Zhou and Lie. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Shao, Liang
Pan, Shan
Zhang, Qiu-ping
Jamal, Muhammad
Chen, Lu-hua
Yin, Qian
Wu, Ying-jie
Xiong, Jie
Xiao, Rui-jing
Kwong, Yok-lam
Zhou, Fu-ling
Lie, Albert K. W.
An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease
title An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease
title_full An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease
title_fullStr An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease
title_full_unstemmed An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease
title_short An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease
title_sort essential role of innate lymphoid cells in the pathophysiology of graft-vs.-host disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563595/
https://www.ncbi.nlm.nih.gov/pubmed/31244831
http://dx.doi.org/10.3389/fimmu.2019.01233
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