Identification of potential inhibitors for Penicillinbinding protein (PBP) from Staphylococcus aureus

Staphylococcus aureus is an infectious agent that causes severe skin and soft tissue infection in hospitalized patients. Therefore, it is of interest to develop potent inhibitors for S. aureus. Penicillin Binding protein (PBP) is a known drug target for inhibition of cell wall biosynthesis in S. aur...

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Detalles Bibliográficos
Autores principales: Kulanthaivel, Langeswaran, Jeyaraman, Jeyakanthan, Biswas, Abir, Subbaraj, Gowtham Kumar, Santhoshkumar, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biomedical Informatics 2018
Materias:
Hypothesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563657/
https://www.ncbi.nlm.nih.gov/pubmed/31223205
http://dx.doi.org/10.6026/97320630014471
Descripción
Sumario:Staphylococcus aureus is an infectious agent that causes severe skin and soft tissue infection in hospitalized patients. Therefore, it is of interest to develop potent inhibitors for S. aureus. Penicillin Binding protein (PBP) is a known drug target for inhibition of cell wall biosynthesis in S. aureus. Hence, PBP was screened with compounds from six databases using virtual screening approaches. Results shows that the screened lead compound produced higher docking score (-9.87 kcal/mol) compared to resistant drugs. Antimicrobial activity using screened lead compounds and resistant drugs showed maximum activity in potential screened compounds compared to resistant compounds.

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