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Cofactor Controlled Encapsulation of a Rhodium Hydroformylation Catalyst

Supramolecular approaches in transition‐metal catalysis, including catalyst encapsulation, have attracted considerable attention. Compared to enzymes, supramolecular catalysts in general are less complex. Enzyme activity is often controlled by the use of smaller cofactor molecules, which is importan...

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Detalles Bibliográficos
Autores principales: Jongkind, Lukas J., Elemans, Johannes A. A. W., Reek, Joost N. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563692/
https://www.ncbi.nlm.nih.gov/pubmed/30624847
http://dx.doi.org/10.1002/anie.201812610
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author Jongkind, Lukas J.
Elemans, Johannes A. A. W.
Reek, Joost N. H.
author_facet Jongkind, Lukas J.
Elemans, Johannes A. A. W.
Reek, Joost N. H.
author_sort Jongkind, Lukas J.
collection PubMed
description Supramolecular approaches in transition‐metal catalysis, including catalyst encapsulation, have attracted considerable attention. Compared to enzymes, supramolecular catalysts in general are less complex. Enzyme activity is often controlled by the use of smaller cofactor molecules, which is important in order to control reactivity in complex mixtures of molecules. Interested in increasing complexity and allowing control over supramolecular catalyst formation in response to external stimuli, we designed a catalytic system that only forms an efficient supramolecular complex when a small cofactor molecule is added to the solution. This in turn affects both the activity and selectivity when applied in a hydroformylation reaction. This contribution shows that catalyst encapsulation can be controlled by the addition of a cofactor, which affects crucial catalyst properties.
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spelling pubmed-65636922019-06-20 Cofactor Controlled Encapsulation of a Rhodium Hydroformylation Catalyst Jongkind, Lukas J. Elemans, Johannes A. A. W. Reek, Joost N. H. Angew Chem Int Ed Engl Communications Supramolecular approaches in transition‐metal catalysis, including catalyst encapsulation, have attracted considerable attention. Compared to enzymes, supramolecular catalysts in general are less complex. Enzyme activity is often controlled by the use of smaller cofactor molecules, which is important in order to control reactivity in complex mixtures of molecules. Interested in increasing complexity and allowing control over supramolecular catalyst formation in response to external stimuli, we designed a catalytic system that only forms an efficient supramolecular complex when a small cofactor molecule is added to the solution. This in turn affects both the activity and selectivity when applied in a hydroformylation reaction. This contribution shows that catalyst encapsulation can be controlled by the addition of a cofactor, which affects crucial catalyst properties. John Wiley and Sons Inc. 2019-01-29 2019-02-25 /pmc/articles/PMC6563692/ /pubmed/30624847 http://dx.doi.org/10.1002/anie.201812610 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Communications
Jongkind, Lukas J.
Elemans, Johannes A. A. W.
Reek, Joost N. H.
Cofactor Controlled Encapsulation of a Rhodium Hydroformylation Catalyst
title Cofactor Controlled Encapsulation of a Rhodium Hydroformylation Catalyst
title_full Cofactor Controlled Encapsulation of a Rhodium Hydroformylation Catalyst
title_fullStr Cofactor Controlled Encapsulation of a Rhodium Hydroformylation Catalyst
title_full_unstemmed Cofactor Controlled Encapsulation of a Rhodium Hydroformylation Catalyst
title_short Cofactor Controlled Encapsulation of a Rhodium Hydroformylation Catalyst
title_sort cofactor controlled encapsulation of a rhodium hydroformylation catalyst
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563692/
https://www.ncbi.nlm.nih.gov/pubmed/30624847
http://dx.doi.org/10.1002/anie.201812610
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