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Kirenol Inhibits the Function and Inflammation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis in vitro and in vivo

Kirenol is a diterpenoid extracted from the Chinese herbal medicine Siegesbeckiae. Siegesbeckiae has been used to treat Rheumatoid arthritis (RA) in China for several centuries. RA is characterized by the proliferation of synoviocytes in inflamed synovia, as well as by their expression of inflammato...

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Autores principales: Wu, Jing, Li, Qiang, Jin, Li, Qu, Yuan, Liang, Bi-Bo, Zhu, Xiao-Tong, Du, Hong-Yan, Jie, Li-Gang, Yu, Qing-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563775/
https://www.ncbi.nlm.nih.gov/pubmed/31244849
http://dx.doi.org/10.3389/fimmu.2019.01304
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author Wu, Jing
Li, Qiang
Jin, Li
Qu, Yuan
Liang, Bi-Bo
Zhu, Xiao-Tong
Du, Hong-Yan
Jie, Li-Gang
Yu, Qing-Hong
author_facet Wu, Jing
Li, Qiang
Jin, Li
Qu, Yuan
Liang, Bi-Bo
Zhu, Xiao-Tong
Du, Hong-Yan
Jie, Li-Gang
Yu, Qing-Hong
author_sort Wu, Jing
collection PubMed
description Kirenol is a diterpenoid extracted from the Chinese herbal medicine Siegesbeckiae. Siegesbeckiae has been used to treat Rheumatoid arthritis (RA) in China for several centuries. RA is characterized by the proliferation of synoviocytes in inflamed synovia, as well as by their expression of inflammatory cytokines. In the present study, we found that Kirenol inhibited the migration, invasion, and proinflammatory of IL-6 secretion of RA-associated synovial fibroblasts (FLS) at a concentration of 100–200 μg/ml in vitro. Proinflammatory cytokines production and synovium hyperplasia and cartilage erosion were also inhibited in a collagen-induced arthritis (CIA) mouse model upon Kirenol treatment. Together, our results thus confirm that Kirenol has potent therapeutic efficacy in RA owing to its ability to suppress negative FLS activities.
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spelling pubmed-65637752019-06-26 Kirenol Inhibits the Function and Inflammation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis in vitro and in vivo Wu, Jing Li, Qiang Jin, Li Qu, Yuan Liang, Bi-Bo Zhu, Xiao-Tong Du, Hong-Yan Jie, Li-Gang Yu, Qing-Hong Front Immunol Immunology Kirenol is a diterpenoid extracted from the Chinese herbal medicine Siegesbeckiae. Siegesbeckiae has been used to treat Rheumatoid arthritis (RA) in China for several centuries. RA is characterized by the proliferation of synoviocytes in inflamed synovia, as well as by their expression of inflammatory cytokines. In the present study, we found that Kirenol inhibited the migration, invasion, and proinflammatory of IL-6 secretion of RA-associated synovial fibroblasts (FLS) at a concentration of 100–200 μg/ml in vitro. Proinflammatory cytokines production and synovium hyperplasia and cartilage erosion were also inhibited in a collagen-induced arthritis (CIA) mouse model upon Kirenol treatment. Together, our results thus confirm that Kirenol has potent therapeutic efficacy in RA owing to its ability to suppress negative FLS activities. Frontiers Media S.A. 2019-06-06 /pmc/articles/PMC6563775/ /pubmed/31244849 http://dx.doi.org/10.3389/fimmu.2019.01304 Text en Copyright © 2019 Wu, Li, Jin, Qu, Liang, Zhu, Du, Jie and Yu. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wu, Jing
Li, Qiang
Jin, Li
Qu, Yuan
Liang, Bi-Bo
Zhu, Xiao-Tong
Du, Hong-Yan
Jie, Li-Gang
Yu, Qing-Hong
Kirenol Inhibits the Function and Inflammation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis in vitro and in vivo
title Kirenol Inhibits the Function and Inflammation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis in vitro and in vivo
title_full Kirenol Inhibits the Function and Inflammation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis in vitro and in vivo
title_fullStr Kirenol Inhibits the Function and Inflammation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis in vitro and in vivo
title_full_unstemmed Kirenol Inhibits the Function and Inflammation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis in vitro and in vivo
title_short Kirenol Inhibits the Function and Inflammation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis in vitro and in vivo
title_sort kirenol inhibits the function and inflammation of fibroblast-like synoviocytes in rheumatoid arthritis in vitro and in vivo
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563775/
https://www.ncbi.nlm.nih.gov/pubmed/31244849
http://dx.doi.org/10.3389/fimmu.2019.01304
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