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Mammalian Target of Rapamycin (mTOR) and the Proteasome Attenuates IL-1β Expression in Primary Mouse Cardiac Fibroblasts

Background: IL-1β is a highly potent pro-inflammatory cytokine and its secretion is tightly regulated. Inactive pro-IL-1β is transcribed in response to innate immune receptors activating NFκB. If tissue damage occurs, danger signals released from necrotic cells, such as ATP, can activate NLRP3-infla...

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Detalles Bibliográficos
Autores principales:	Torp, May-Kristin, Yang, Kuan, Ranheim, Trine, Husø Lauritzen, Knut, Alfsnes, Katrine, Vinge, Leif E., Aukrust, Pål, Stensløkken, Kåre-Olav, Yndestad, Arne, Sandanger, Øystein
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563870/ https://www.ncbi.nlm.nih.gov/pubmed/31244838 http://dx.doi.org/10.3389/fimmu.2019.01285

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