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Structures of the Otopetrin Proton Channels Otop1 and Otop3

Otopetrins (Otop1–Otop3) comprise one of two known eukaryotic proton-selective channel families. Otop1 is required for otoconia formation and a candidate mammalian sour taste receptor. Here we report cryo-EM structures of zebrafish Otop1 and chicken Otop3 in lipid nanodiscs. The structures reveal a...

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Detalles Bibliográficos
Autores principales:	Saotome, Kei, Teng, Bochuan, Tsui, Che Chun (Alex), Lee, Wen-Hsin, Tu, Yu-Hsiang, Kaplan, Joshua P., Sansom, Mark S. P., Liman, Emily R., Ward, Andrew B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6564688/ https://www.ncbi.nlm.nih.gov/pubmed/31160780 http://dx.doi.org/10.1038/s41594-019-0235-9

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